I've only been on Accutane (actually, a generic brand of it) for ten days, and I experienced my first migraine on day 9. I am unsure if the migraine could be connected to Accutane, but I did a little research and some instances of migraines have been reported by Accutane users. I am just uncertain because I haven't been on it very long, but I am already experiencing dry lips, so I suppose I could be experiencing other side effects already, too.