
mild acne flare, dryness of skin, lips and mucous membranes, infection of the cuticles, itch, skin fragility, skin peeling, rash, flushing, photosensitivity, nose bleeds, dry eyes, eye irritation, conjunctivitis, reduced tolerance to contact lenses, hyperlipidaemia, raised liver enzymes, headaches, hair thinning, muscle pain, joint pain and back pain. Reference: http://en.wikipedia.org/wiki/Isotretinoin
If it persists, it is best to inform your doctor and discuss alternative medications.