Morphine oxycodone conversion

Common Questions and Answers about Morphine oxycodone conversion

avinza

I've been undergoing a <span style = 'background-color: #dae8f4'>morphine</span> to fentanyl conversion since January. This is being done against my will. I was stable on 90mg. morphine 4x day for over 10 years, last August 2012 my dr. informed me my dose was too high and he would no longer prescribe it for me. He was a new dr., my last one left Kaiser. Started decreasing my morphine monthly, it didn't go well. Pain way up, withdrawals, overall sadness. Finally in Jan.
I am presently on pain management and take one 10 mg oxycotin twice daily and 22 mg oxycodone 4 times a day for break through pain. my dcotor tried switching me over to <span style = 'background-color: #dae8f4'>morphine</span> ER 30mg twice a day and 5 mg oxycodone when needed for break through pain. what would be the correct conversion for the oxycodin and oxycondone and the morphine ER and morphine sulfate instant as I would rather be on the less potent drug and want to wean off the oxycodone and oxycodin.
Meperidine (Demerol) 10-20mg.........Methadone 30-60mg.........<span style = 'background-color: #dae8f4'>morphine</span> 20mg..............Oxycodone (Oxycontin, percocet) 10mg..............Oxymorphone (Numorphan) 200-300mg.....Propoxyphene (Darvocet) 150mg............Tramadol (Ultram, Ultracet) a guide only...
Ask your doctor to do a liver function test (AST/ALT and ALP) while everyday on paracetamol and see for yourself. On the other hand, <span style = 'background-color: #dae8f4'>morphine</span>, hydro/oxycodone (without paracetamol) in the doses you're taking, are highly unlikely to cause any liver toxicity.
Buprenorphine (Bupe) 200mg............Codeine (Tylenol 2, 3, 4, etc) 30-60mg.........Diacetylmorphine (Heroin) (orally it = <span style = 'background-color: #dae8f4'>morphine</span>, IV/IM/insuffilated it's 2x as strong) 100mg............Dihydrocodeine 30mg..............Hydrocodone (Vicodin, Lorcet, etc) 7.5mg.............Hydromorphone (Dilaudid) 37.5µg............Fentanyl (not sure on this one, anyone know the oral dose equivalence for Fentanyl?) 4mg................Levorphanol (Dromoran) 300mg............Meperidine (Demerol) 10-20mg.
The abuse potential of oxycodone is equivalent to that of <span style = 'background-color: #dae8f4'>morphine</span>. The usual indications for oxycodone are severe acute postoperative or posttraumatic pain and cancer pain. When oxycodone is administered, the same precautions should be taken as with morphine or other agonist opioids." "Oxycodone is an effective opioid analgesic for cancer pain.
So I went from taking 12 5/325mg percocets a day to 5mgs of <span style = 'background-color: #dae8f4'>morphine</span> sulfate 2times a day. And after 24hours, boy was I sick, horrible flue like symptoms, chills, shaking, sweats, fever, teeth chattering, it was like nothing I had ever experienced before! So I went to see my obgyn after 2days of that, she put me back on the percocet. But I still am left wondering, what the heck was that? Withdrawals? A bad reaction? I must say after reading on here, I think it was withdrawals!
If you were getting adequate relief from the percocet, I don't know why he switched you to <span style = 'background-color: #dae8f4'>morphine</span> to get away from tylenol, all he had to do was give you pure oxycodone in the immediate release form. It comes in dosages as low as 5mg, it's not like oxycontin, which is the time-release version. If I were you I would ask him about it. There is no point to taking something that isn't giving you any relief.
The Fentanyl, which I'm on for my Long-Acting Med, is approximately 80 times stronger than <span style = 'background-color: #dae8f4'>morphine</span>. The Oxycodone (I use percocet 10/325's for my BT Pain) is not as strong as the Fentanyl. Which meds are you on for your pain? As I said above, I'm very happy that you have found this site and I hope that you will enjoy the support that we offer here for you!! You might also, enjoy the Cancer Forum's. Here's the Link: http://www.medhelp.
Since there is no entry for the patches, I modified it based on a conversion table I found. I was shocked to find out that the 100mcg fentanyl patch is equivalent to over 200mg of oxycodone per day!! HOLYCOW! I wish I was smarter BEFORE I let the doctors put me on that ****.
but it is not really the effect they r comparing//but the strength...i do believe there is a conversion chart in avisg's journal...
Hi Ddiane, Welcome to the Pain Mangement Forum. Your physician will be the best source to determine the correct conversion dosage. There are charts on the www that compare narcotic dose to narcotic dose but again your physician should be the one to make that determination. Fentanyl is approximately 80-100 times stronger than morphine, depending on who or what chart you beleive. However it is indisputably stronger than most opiates.
30 mg of Opana ER is roughly 60 mg of oxycodone or 90 mg of <span style = 'background-color: #dae8f4'>morphine</span>. 10 mg of Opana ER is roughly 20 mg of oxycodone or 30 mg of morphine. You are actually getting 5 mg less of oxycodone through the switch from percocet to Opana ER. However, since Opana ER is an entirely different opioid formulation. There is probably some cross tolerance and your doctor applied a 20% cross tolerance factor when converting you from oxycodone to Opana ER.
The Essentials Positive mindset A multivitamin Courage Determination An understanding that this is not forever. Diarrhea Immodium A.D. - 4-6mg loperamide per 50-60mg of oxycodone/hydrocodone. (May vary!) Try not to take this too often as it can make you REALLY constipated, but it can get rid of (in my experience as well as others) the majority of the physical withdrawal symptoms. Just remember that loperamide is an opiate, so it's better to only take if NEEDED.
For example, for some opiates, the administered medication is a 'prodrug' that must be converted to the active drug by the liver; an example is the conversion of codeine to morphine, which is more efficient in some people than in others. There is also wide variation in the degree of nausea produced by different medications in different people. I do not know of any evidence that hydromorphone is better tolerated overall than oxycodone.
Smart move - I believe that it is basically <span style = 'background-color: #dae8f4'>morphine</span>. The human body handles <span style = 'background-color: #dae8f4'>morphine</span> a lot better that synthetic opioids like oxycodone, as the liver naturally produces small amounts of this natural substance.
Oxycodone is about half as strong as Oxymorphone per mg. So you were talking 60mg of Oxycontin (Oxycodone) and going by a Opioid (Narcotic) analgesic converter you would need 30mg of Opana (Oxymorphone) to get the same pain releif and most likley the same to cover the withdrawl. You are now taking 10mg of Opana where 30mgs is what the converter says you need. You need to talk to your Dr. about dosage and don't take more than your Dr wrote the Opana for until he or she OKs it.
It is approximately 6–8 times more potent than <span style = 'background-color: #dae8f4'>morphine</span>, and is related to <span style = 'background-color: #dae8f4'>morphine</span> in the same fashion that oxycodone is to codeine (being a derivative of thebaine). It differs from morphine in its effects in that it generates less euphoria, sedation, itching and other histamine effects. Depending on the individual patient, it can be either more or less nausea- and vomit-inducing than morphine.
My guess is that you are on to low of a fentanyl dosage, compared to your oxycontin (oxyneo is the same I think) and percocet dosage. They have conversion charts available on most medical websites. You can check it yourself before going back to the doctor. I wouldn't be afraid to tell him the patches aren't working, and that you think the dosage is to low, especially if the conversion charts "back you up". just don't "demand"a dosage increase, let the doctor be the doctor.
5 times stronger than <span style = 'background-color: #dae8f4'>morphine</span>; hence, 40 mg of oxycodone = 40*1.5 mg of <span style = 'background-color: #dae8f4'>morphine</span> per day (i.e., 60 mg) for breakthrough pain. I also take 60 mg of morphine sulfate ER total per day split in 30 mg doses every 12 hours. If you add the morphine equivalent dose of oxycodone (i.e., 60 mg) with the 60 mg of morphine sulfate ER you get 120 mg per day. Now, converting that to Opana ER. Opana ER is 3x stronger than morphine; hence, 120 mg of morphine = 120/3 mg of Opana ER per day (i.e., 40 mg).
I've made the switch from the oxycodone to the <span style = 'background-color: #dae8f4'>morphine</span> last night. Woke up today feeling not so great, but I can do this. Next appointment is Monday morning where we'll review the taper and see where to go. I have to keep reminding myself I didn't get to these doses overnight and I'm not going to get rid of them overnight. The withdrawals for me are different than when I tried to go cold turkey. Still bad but not as severe.
And the dangers with Fentanyl, especially as it comes in Micrograms and not milligrams...it makes conversion even more tricky. We live in a world where there are people who scour the internet all day and read sites like this and use them in ways that they shouldn't...I am NOT trying to say you, or even the OP...but this is why I don't post things like the conversion tables or things in that way as I don't ever want to say that it's ok to use them ourselves... So...
Hi Mark, Kadian is <span style = 'background-color: #dae8f4'>morphine</span> in long acting form. And Norco contains hydrocodone along with acetaminophen (tylenol). Based on the opioid conversion table, 17 mg of hydrocodone is equivalent to 10 mg of morphine. Therefore, 20 mg of Kadian is equivalent to about 34 mg of hydrocodone.
) for some medication for breakthrough pain (instant release, or fast acting) such as percocet, oxycodone, vicoden, etc. I like oxycodone for breakthru pain the best because there is no tylenol in it to worry about. Quick release morphine is also a very effective fast acting painkiller.
3 months ago an MRI revealed buldging discs (L4/5 and S1) and I have been taking Oxycodone and receiving epidural injections (which do not help). The pain is only getting worse all the time. My Neuro said I cannot be helped by surgery, but I have made an appointment with an Ortho to confirm that opinion. A few weeks ago he added morphine to my meds, but the pain is simply increases every day.
It is spelt Codeine,and it really sucks,get the Hydrocodone or Dihydrocodeine,or the oxycodone or maybe oxymorphone,then again why not morphine?.Codeine makes me SICK.Did you know that even though Codeine is a "Natural" Opioid all of the Medical Supplies are actually made by Methylating morphine in a Pharmaceutical laboratory(not exactly natural)is it then?. Go the morphine,kill to get it if you have to,well maybe a few Opium Poppies anyway.
The major discovery is that the classic opioids like <span style = 'background-color: #dae8f4'>morphine</span>, oxycodone, fentanyl, and Dilaudid (hydromorphone) break down into metabolites that are 'hyperalgesic', that is, molecules that can actually cause pain when they accumulate under conditions of chronic administration. This might explain the experience of switching to more and more potent opioids which in turn produce more and more hyperalgesic molecules, and so a vicious cycle develops. Methadone is different.
conversions for fentanyl are based on a <span style = 'background-color: #dae8f4'>morphine</span> dose over a 24 hour period. Oxycodone is apx 1.5 times stronger than <span style = 'background-color: #dae8f4'>morphine</span>. If you take 12 pills a day, assuming they are 10mg/pill.....you take apx 120mg of oxycodone per 24hours. This would equal out to about 180mg of morphine to obtain the same level of relief. Literature suggests for a 24 hour morphine dose of 60-134mg you would need a 25mcg fentanyl patch. So you would be right around a starting patch of 50mcg.
I have been going to a pain management/spinal doctor for the past 2 months and am on Oxycodone, Kadian, Neurotin(sp?), & have just started the 12mcg patch of Fentanyl today (5/8/09). I am wondering what can I expect from this patch - the good, the bad & the ugly? I am not a newbie to oral pain meds as I was in a pretty bad car accident 11 years ago where I crushed part of my knee & messed up my leg. But, the pain patch thing is totally new to me.
Many doctors don't realize that the analgesic activity of codeine comes almost entirely through conversion to <span style = 'background-color: #dae8f4'>morphine</span> at the liver by an enzyme referred to as 'G6PD' (glucose-6-dehydrogenase). There are varying levels of this enzyme in the general population, and hence varying responses to codeine. Some people find that Tylenol #3 gives them nothing but a headache; others get significant pain relief from the medication. More dangerous, though, are the effects of acetominophen on the liver.
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