Ibuprofen and liver enzymes
Common Questions and Answers about Ibuprofen and liver enzymes
ibuprofen
This past 2 weeks I was ill with the h1n1 virus. During the 2 weeks, I consumed over 50 200mg pills of ibuprofen. I have had blood work done twice (5 days ago and 2 days ago). Both resulted in increased liver enzymes. I haven't had any ibuprofen in 4 days. Is it possible that my liver enzyme increase is a result of the "overdose" with the ibuprofen. My doctor has scheduled another blood work screening in two weeks. Will my liver enzymes decrease in this amount of time?
I recently went to a G.I. doctor. I had some liver tests done and my liver enzymes came back "slightly elevated". Back in 2005 my AST & ALT were at 17 * 18. They currently register at 46 & 48 for AST & ALT. I am a 29 yr. old female w/ a number of gastrointestinal problems. I was born without a gall bladder, I have irritable bowel syndrome and I quite possibly over use ibuprofen, taking as much as 800-1600mg/ day. Are these levels high?
is needed and because my liver enzymes, chemistires wre within normal range, I did not have advanced liver disease and was able to loterate the treatment better if I took tylenol/ibuprofen for cramps the benefit outweighed the risks...many of the statistics and people I have spoken with who did not complete the treatment cited the horrible aches, pains, fatique as a reason...
Over-the-counter meds like Tylenol and NSAIDs like Ibuprofen and Naproxen Sodium can also cause elevated liver enzymes. Statins taken for cholesterol often cause elevated liver enzymes and also some common antibiotics.
Exposure to certain toxins in the home or workplace can be the cause also.
Here's an article that lists some medications that can result in elevated liver enzymes:
http://www.medicinenet.com/drug_induced_liver_disease/page8.
Acetaminophen has been known to cause liver problems and I, for one, can only use it sparingly, due to liver conditions. I would try to eliminate or moderate alcohol consumption and I would eliminate the Tylenol PM. Unfortunately I'm not aware of any liver friendly pain or sleep remedies. Acetaminophen, Ibuprofen, Naproxyn, etc., all tend to have negative effects on the liver. I hope this helps.
Many conditions can cause high SGPT like liver inflammation, fatty liver, injury to the muscles, myocardial infarction, and acute kidney failure. Fatty liver is the common cause of mildly elevated SGPT. Refrain from alcohol. See a physician and get evaluated for determining the above possibilities. Treatment will depend on the exact cause of your symptoms. Keep me posted with more queries.
Best luck and regards!
Hi,
One of the most common causes of elevated liver enzymes is medications. Over-the-counter meds like Ibuprofen,Tylenol, Naproxen Sodium and also some common antibiotics can cause elevated liver enzymes. Statins taken for cholesterol often cause elevated liver enzymes.
This list is from the Mayo Clinic:’
http://www.mayoclinic.
Studies have demonstrated that at certain dosages, ibuprofen can stress the liver and elevate liver enzymes in people with Hepatitis C. Ibuprofen must be used with extreme caution in the later stages of liver disease and for those on interferon therapy.
3. Aspirin – (Bayer, Anacin, Excedrin and others) reduces fever, relieves pain, and acts as an anti-inflammatory and blood thinner.
My liver enzymes were recently checked by my endocrinologist and found to be high, too. I, too, have been fighting fatigue for the past couple of years. I've also had strange neurological issues. The liver enzymes being elevated is new for me, though. My numbers aren't as high as yours--mine are 165 (ALT) and 109 (AST).
Your doctor needs to rule out things like HIV and hepatitis. In addition to all those tests, you might also ask about getting tested for Lupus, too.
ALT Blood Test
ALT (SGPT) A Liver Function Test
The ALT (SGPT) blood test is one that measures the levels of the liver enzyme alanine transaminase (ALT) in the bloodstream. Liver enzymes are generally contained in the cells of the liver; however there are a number of diseases and conditions that cause them to spill from the liver into the bloodstream. Through blood testing doctors can determine the type of enzymes, make a diagnosis and determine the need for any additional testing.
170
My ultrsound for liver and spleen 2 weeks ago was normal. Do I worry unnecessarily? Since I do not have older tests, I do knot know my previous values. I have NAFLD or NASH and I am 35 years old. I was overwihjt in last 4-5 years (with a maximum BMI: 28.2 during that period) .
My liver enzymes are normal in last 8 months.
What do you think from platelet count?
whenever i take even one 550mg (naproxen) ibuprofen and then drink, my stomach gets tender and bloated and i feel bad. i usually take a maalox or something like that, yet i never throw up from it so i don't know if that's applicable for you. i think it is due to the ibuprofen, but if you're not used to eating spicy foods then it could have disagreed with you, not necessarily meaning food poisoning. you should never drink and take NSAIDs at the same time.
the results indicated AST had gone down to 50 and ALT down to 60, but hepatitis C antibodies were present. Between the first and second test I cut out the tylenol and ibuprofen i had been taking for muscle and joint pain after reading about hepatotoxicity, i believe cuting the medine out may have had a positive effect on my AST and ALT levels. I am now awaiting anxiously for the results of the third test to see if i have a current HCV infection.
It causes liver toxicity, and serious liver damage. Tylenol is one of the leading causes of liver failure in the United States, accounting for an estimated 450 deaths per year. I quit taking Tylenol years ago, I recommend you do the same. I found that Naproxen or "Aleve" is about the safest. Ibuprofen and asprin are hard on the kidneys.
I hope this has been helpful!!!
But it must be emphasized that higher-than-normal levels of these liver enzymes should not be automatically equated with liver disease. They may mean liver problems or they may not. The interpretation of elevated AST and ALT levels depends upon the whole clinical picture and so it is best done by doctors experienced in evaluating liver disease.
The precise levels of these enzymes do not correlate well with the extent of liver damage or the prognosis (outlook).
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