It has an active metabolite, norfluoxetine, which has a very long
half-
life (4-14 days) - so it can take about five weeks to fully get rid of it. This may be an advantage, as the chance of getting the "SSRI withdrawal syndrome" is far less.
I took Mirtazapine together with Zoloft. I didn't suffer any depression, but quite a lot of anxiety. I remember feeling more happy on Mirtazapine, I slept well, and felt like I had more energy the next day.