Zonisimide is indicated for seizure disorders while Amitriptyline is an antidepressant drug. Some of the
side effects of Zonisimide include dizziness, headache, nausea, vomiting and trouble sleeping. (http://www.medicinenet.com/zonisamide-oral/article.htm). Amitriptyline, on the other hand may cause any of the following effects:increased heart rate, blurred vision, urinary retention, dry mouth, constipation, weight gain or loss, and low blood pressure on standing. (http://www.medicinenet.