warfarin and drug interactions

Enhanced hypoprothrombinemic response to warfarin has been reported in patients with acute alcohol intoxication and/or liver disease. The proposed mechanisms are inhibition of warfarin metabolism and decreased synthesis of clotting factors. Binge drinking may exacerbate liver impairment and its metabolic ability in patients with liver dysfunction. The risk of bleeding may be increased. Conversely, reductions in INR/PT have also been reported in chronic alcoholics with liver disease.

I have been on Coumadin for 18 years due to Lupus Anticoagulant (Antiphospholipid Syndrome) and several DVTs. In 2005 had MI with occlusion of the LAD artery and had drug stent inserted and I am still on plavix. My doc has debated when to take me off the Plavix safely....what are the recent studies about this dilemma? thanks so much!

To date there have been no reports of an important interaction in humans between warfarin and clopidogrel. Nonetheless, because warfarin increases the risk of bleeding, blood tests to measure the degree to which the blood is anti-coagulated or thinned (prothrombin time; INR) may be ordered to assess the degree of blood-thinning when warfarin and clopidogrel are used together.

These visits come with their co-pays and deductibles too! Not to mention that warfarin has significant risks, drug interactions, food restrictions etc. And overall: you have to think of the worse case senario of switching to warfarin having the warfarin be too strong and your wife getting a bleed of some kind. This could be in her GI track, brain etc. and can be very life-threatening and could cause huge hospital bills.

The clearance of R-warfarin is generally half that of S-warfarin, thus as the volumes of distribution are similar, the half-life of R-warfarin is longer than that of S-warfarin. The half-life of R-warfarin ranges from 37 to 89 hours, while that of S-warfarin ranges from 21 to 43 hours. Studies with radiolabeled drug have demonstrated that up to 92% of the orally administered dose is recov-ered in urine. Very little warfarin is excreted unchanged in urine.

Coumadin is known for having many drug-drug and drug-food interactions, which can make you over or under coagulated. For instance, since it works by being a vitamin K antagonist, foods that contain vitamin K (like leafy greens) can lower your INR. Taking vitamin E or fish oil or aspirin could raise it, and make bleeding more likely.

I am concerned about possible drug interactions between the antibiotic azithromycin and the two heart medications warfarin and amiodarone. My relative has brief history of heart problems span one and a half years (though the underlying heart condition itself appears to be congenital). Rhythm problems resulted in CHF, hospitalization, and later diagnosis and heart surgery. Subsequent dysrhythmia and CHF has been prevented adequately with medication.

Loading doses of warfarin are not warranted and may result in bleeding complications. Interactions with other drugs must be considered, and therapy in elderly patients requires careful management. Current dosing recommendations are reviewed, and practical guidelines for the optimal use of warfarin are provided". Hope this helps, and if you have any further questions or comments you are welcome to respond. Thanks for your question. Take care.

My psychiatrist, who I see every 2 months, is starting me on Lithium low dose (300 MG/day) and he said it could have interactions with some of my heart meds, lasix in peticular, but didnt go into much detail and said things should be fine. I dont see my cardiologist for another 2 months, and my GP till January 4th (I see him every two weeks). I am extremely nervous about taking the lithium without knowing anything about it and how it can interact with the lasix or other meds.

There're few web sites that shows "drug interactions", and "drug/herb/food interactions" ...do a search online for words in " ",I am sure you'll find your answers.....if not, please feel free to message me and I'll send you a link.

Prozac now 40mg and fentanyl 50mcg. and he is now talking in his sleep every night and constantly scratching at himself in his sleep.

Potential side effects include drowsiness, dizziness, blurred vision, headache, and nervousness. Because the combination of chlordiazepoxide and alcohol (ethanol) may impair your judgment and/or reflexes, it may be dangerous to drive or to perform tasks which require you to be alert after taking these together. It would be advisable to avoid consuming alcohol while you are taking chlordiazepoxide.

I just went up to the booth when I was picking up the amtriptyline and said I have an old rx for ultram and the doctor said It was ok to take with the amtriptyline and she said yes. Then of course I come home and put it in the computer where I keep all my prescribtions for any recalls and it comes up it may cause seizures. I am guessing if you are on a very high does of amtriptyline but I only take .10-.20 so that is very low. It is used for pain managment and not for depression.

This morning the pain is still there as is some slight nausea though I was able to eat something. Does anyone know of drug interactions between Anacin and Progesterone? Is there something else it could be?

I would look at the birth control pill in relation to your thyroid medication and disease, and also the consequences of mixing the birth control and the Prozac. You may find that switching birth control will allow for treatment other than Prozac. Just a thought, but I think it has merit. Keeping up on your bloodwork and getting stable at the correct level is the best medicine. If Prozac helps short term, go for it. I'm taking xanax.

I take 24mg suboxone daily. Iam bi-polar and was prescribed pristiq and abilify, after i went on the suboxone, which i did not tell the doc i was on. I took my first dose of the meds, the abilify and pristiq, (which i had been on before) and got deathly ill, for about 6 hours, then i felt drugged until the next day. I have not tryed it again. Iam only on the suboxone, but i want to get off of it, it has changed my life for the better, in every way, except the cost.

Warfarin and drug interactions

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