Sorry but truvada is not ok in case of tdf resistance , which is only theory because there is notone single case of naive treatment developping resistance.the other antiviral in combo is too weak and similar to lamivudine, it also shares lamivudine mutants and resistance
the correct choice is entecavir which combo with tdf cross protect from development of any resistance
i think there are many tries from drug makers to push truvada because the patent will expire after many years.
i think tdf is more than enough for hbv, no need to add possible sides, i myself hope to discontinue etv sooner or later.
has anyone been prescribed Truvada? If so I would like to know how you are doing with it? and if it is helping your hepatitis b? I have stage 4 kidney disease. My hepitologist just prescribed this med. My labs were not good. He hopes to get the virus under control so I can possibly get a kidney transplant. This would be a kidney from a cadaver donator, someone who had hepatitis b. So I am about to begin my journey.
Hi,can anyone tell me what are the medical options remaining after being resistant to both lamivudine 100 and entecavir 0.5?Will tenofovir 300 alone or ETV+TDF or any other Combo work?Please share your views?
Try Truvada. There are reports that it clears surface antigen at 11% per year. The benefit of interferon still will be there as it had a long lasting effect.
But etv + tdf is also a good combo. It is just truvada is optimised combo to be less toxic.
From taking entecavir for 6 years i can tell you one thing that just about all drugs enhance etv and sometimes the associated headaches are tough to cope with. And from what I take tenofovir is an even more potent drug with a higher dose.
Tenofovir alafenamide (TAF), a new formulation that reaches higher levels in cells but allows for lower dosing, was as effective as the current tenofovir disoproxil fumarate (TDF) formulation but had less impact on markers of kidney function and bone turnover, researchers reported at the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2013) this week in Denver.
in case you are in immune tollerance phase you need tdf+etv or tdf+ftc (truvada) to make hbvdna low and once undetectable you need peginterferon add on to have an immune response so that antivrals can be stopped or hbsag cleared
we have a member, i think nick is something like asianmale, he was treated while on tolerance phase and made tdf+etv combo to make hbvdna und and then added pegintf and cleared hbsag.
I read somewhere that there are reports out there that Truvada along can clear hbsag at around 10% per year. Which is if true makes it the best antiviral option for us from what is available.
Lets share ideas on this.
The way I see it it is a powerful combo for hbv. 200mg of tdf and 200 emtricitabine.
tenvir is generic version of tenofovir
tenvir tm is generic version of tenofovir+emtricitabine (truvada) which even more potent than tenofovir alone
entecavir is less potent of both tdf or truvada, i am also on entecavir which is about 1000usd per month changing currency from euro, i have it free in my country but it is absurd to allow such costs for a stupid tablet
http://www.aids-drugs-online.com/productindex.
While Tenofovir has a dramatically lower inherent chance to go into resistance compared with Adefovir ( almost 30 fold power) , the fundamental consideration is the same. If resistance would develop to the TDF/LAM combo, Entecavir would still work, limpingly, but secondary resistance could be expected. Somewhat higher expectations of effectiveness/ resistance preventive power can be placed in the use of the FTC/TDF combo a drug already in use for HIV under the name Truvada.
or other adverse events when they used or stopped using Truvada for HIV pre-exposure prophylaxis (PrEP), according to an analysis from the iPrEx study presented at the Eighth International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015) last month in Vancouver, Canada. This is a potential concern because the drugs in Truvada – tenofovir and emtricitabine – are active against HBV as well as HIV.
Thanks for the reply
I guess you can never be to careful nowadays even with healthcare protocols.
These clinical case reports, isn't it only if your viral load is low or hbeag is neg? I'm still in the immune tolerant stage with viral load in the millions...
I'm a CHB, on etv and tdf combo since for 18 months , this is the first time to have an increase in serum phosphurs about 7.7 mg/dl (Normal 2.3 to 4.7) as well decreased eGFR about 70 ..
I am 27 years old ..
your suggestions ?
s a fact so i think we should check what alinia+etv or +tdf or +truvada does because this is available now with no sides since alinia has shown higher seroconversion than interferon and nucs
i think nucs are ok only for f3/f4 damage to save people from cirrhosis
- interferon plus etv or tdf or truvada are on trial now so most should wait the results since interferon can have heavy sides.
this confirms that the currenct use of antivirals like entecavir and others is just marketing, all antivirals except tenofovir are risky for patients since the mutants take years before they show up it is easy that many are carrying etv mutants even if hbvdna is undetactable for 3-5years
since tdf is cheaper and carry no danagers like this it is meanless to keep using other antivirals as monotherapy
glucose fully normal, cholesterol and all metabolic parameters in super healthy range, i really fear its tdf because i had some creatinine issues even before switch to tdf while on entecavir but maybe it was the use of nitazoxanide at that time and i recovered fully by use of fibroguard in those years
the possible sides effects of tdf or truvada are on patients with damaged kidneys already
there are no tests to know if kidneys are damaged (and many drugs like antibiotics or painkillers do damage without any tests showing this) so the only way is start antivirals and in case there is a rise of creatinine you know your kidneys were damaged and cannot stand any drugs
this happens on about 1-2% of patients o it will surely be not your case, i think the doctor just wants to be extra safe by check
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sorry for got to say truvada is used on hiv-hbv coinfection at the moment from many years, it is still on trial for hbv monoinfection but the combo of 