l have had a look a a website that someone suggested on hep c drup trials and l see that there are some trials that appear to only use the protease inhibitors without the inteferon and riba. If this is so, has anybody had any expeience, and success with such trials?
Keep in mind that in order for protease inhibitors to be effective, they need to be taken on time, and at the right dose. It is important to tell your doctor if you are having trouble sticking to schedule because of side effects. There are ways to manage these side effects. Your doctor may reduce the dose, or switch you to another drug.
http://www.atdn.org/simple/protease.
Protease inhibitors: Hepatitis C viruses use an essential enzyme called protease (pro-tee-aze) during their replication process. Certain drugs can interfere with this enzyme which stops the virus' ability to copy itself. Drugs of this type that have reached the market for treating chronic hepatitis C are Victrelis and Incivek.
Polymerase inhibitors: Each time hepatitis C viruses replicate, they use an enzyme called polymerase to copy their RNA (genetic code).
Copy and paste this link into your browser. It will get you to a list of site pages:
When you get there, just click on the top site. The video should start by itself.
http://hepatitiscnewdrugresearch.com/watch-how-hepatitis-c-protease-inhibitors-work.html
After the first presentation finishes, then click on the next part you want to watch (Incivek or Victrelis).
The 2 newest major types of drugs being tested are protease and polymerase inhibitors. They are drugs that effect the virus replication process. As of now pegylated interferon and ribaviran are the only FDA approved methods of treating hep c. The others are in in trials but show a lot of promise and some have had very good results, some have been scraped because of problems.
Due to the risk of life-threatening and fatal toxicity, patients with renal or hepatic impairment should not be given colchicine in combination with potent CYP450 3A4 inhibitors such as itraconazole, ketoconazole, voriconazole, nefazodone, delavirdine, protease inhibitors, and ketolide and certain macrolide antibiotics. In patients with normal renal and hepatic function, the dosage of colchicine should be reduced when used with potent CYP450 3A4 inhibitors or within 14 days of using them.
The company said that 518 has been shown to be 10 times more potent in-vitro than other protease inhibitors currently in Phase III development and has the potential for once daily dosing. The protease inhibitor also has shown decreased emergence of resistance in vitro. Given its pharmacokinetic profile, the company anticipates that 518 may be active against some HCV strains that are resistant to other protease inhibitors.
we are hopeful that one of two protease inhibitors will be available and FDA-approved by this time next year. These would augment current interferon-based therapies. Consensus interferon is currently available for some people who have suboptimally responded to interferon therapy and may have some utility. There are numerous clinical trials ongoing that include other protease inhibitors and small molecules. albuferon will hopefully also be available soon.
Stating as fact "(protease inhibitors to be released in 2011) " is misleading because it's really only speculation. At this time, no one really knows for sure when the PIs will be available. I read a financial article last week from a reputable site that projected that Telaprevir could be released as early as late 2010. But, I wouldn't state it as a fact.
They are showing very good results when added to the current standard of therapy of Interferon and ribavirin . Eventually they will probably have cocktails of protease and polymerase inhibitors that will hopefully have even better results and will not require the interferon and ribavirin which is so hard on the body. You can search for information on this forum about them or on the internet.
The company said that 518 has been shown to be 10 times more potent in-vitro than other protease inhibitors currently in Phase III development and has the potential for once daily dosing. 518 also has shown decreased emergence of resistance in vitro. Given its pharmacokinetic (PK) profile, the company anticipates that 518 may be active against some HCV strains that are resistant to other protease inhibitors.
Most importantly, protease inhibitors are potent CYP3A4 and p-glycoprotein inhibitors, and they dramatically increase exposure to drugs that are metabolized by these pathways. For example, exposure to calcineurin and mammalian target of rapamycin (mTOR) inhibitors, the foundation of immunosuppression in transplant recipients, is dramatically increased when recipients receive protease inhibitors, making drug toxicity a real possibility.
G&H Are there any ways to reduce these risks?
I have heard of it. It is schering-plough . It is a stronger boceprevir(10 times stronger) and you take it less time and less doses a day. It's in trial now for tx naive. It's called next-1 I think. I was hoping that they would be having one for a relapsers with this med. but not yet.
s such as NS5A and polymerase inhibitors which you may consider, but personally I think the best route is one of the newer protease inhibitors (TMC 435 or such) and a polymerase inhibitor. It is likely that they will eventually have clinical trials to test protease inhibitors on those who failed early protease inhibitors.
Options are coming.
Hang in there.
This is known. Are there any similar action in the protease inhibitor, such as Kaletra (lopinavir) for example?
Have you ever thought about that?
I read - sometimes laugh. Simvastatin, vitamin D, which the Chinese poeben, mythical new drugs, masturbation with measurements of the level of HBsAg, and other nonsense....
What happens, though, if you're not able to do the Protease Inhibitors? Some of us have resistance issues to Protease Inhibitors due to being exposed to either Telaprevir or Boceprevir w/o viral clearance, or had breakthrough virus and now..., have resistance. I am way more likely to go with a treatment that does not involve any protease inhibitors due to my resistance to Telaprevir.
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