Tiotropium and muscarinic receptors
Common Questions and Answers about Tiotropium and muscarinic receptors
spiriva
Somebody also suggested that the chemical stress also affects the PSNS muscarinic receptors causing secretion increase and other symptoms. Tranquilizers work to a certain extent.
L.
I take Spiriva Respimat (tiotropium bromide) 2.5 mcg/actuation, and Wixela (fluticasone propionate salmeterol inhalation powder) for my COPD. Is there a sequence I should be taking these meds in? Is there a time frame I should use between the two meds?
Yes, there are. Spiriva® HandiHaler® (tiotropium bromide inhalation powder) is one and Serevent® Inhalation Aerosol (salmeterol xinafoate) another. Each is a bronchodilator and capable of giving good relief of shortness of breath.
I was told to stop my spiriva in Aug. that I had been using for about 3 yrs. This was after I had a PFT for the first time. I've had three ct scans over the past three yrs. Shows granulomata and calcified nodules..no change. For the past couple of days I've been very SOB and my arms feel weak and heavy. My chest doesn't hurt it just feels tight/full. Today has been worse. I was also put on neurontin 1 1/2 weeks ago for headaches and wonder if that could have anything to do with it.
s comment about drops, this article mentions the following regarding the class of drugs including atropine - these are called Anti-Muscarinic drugs and in general they cause pupil dilation and can also paralyze the focusing muscles surrounding the eye's natural lens:
"Anti-Muscarinic Therapy: A recent review that included 23 clinical investigations of myopia treatments in children found that anti-muscarinic medications (eye drops) had the largest positive effects for slowing myopia pr
Sorry to say, there are no cures, but there are good treatments, especially with inhaled medicine. If you have not already stopped smoking cigarettes, you must stop immediately. Then you should begin respiratory medicine for this condition.
Can someone explain to me in medical terms the danger/affect there in mixing a muscarinic M3 receptor antagonist that inhibits acetylcholine-induced contraction of smooth muscle, i.e. respiratory, digestive and urinary tract(s). I recently relapsed after 2 years sobriety after having the PROMETA treatment, a neurotransmitter reversal of sorts and have a good grasp of medical terms.
This was last February. I survived 23 days of utter hell and felt free and clear after about a month. I beat it, I thought. Life was beautiful again! lol I truly felt great.
About two months later, my soccer team won a big tournament and I wanted to celebrate so I found one of my old stases and BAM I was once again a full-blown (instead of a recovering) addict. I didn't think I could survive another 23-day hell sentence so I made my second biggest mistake and tried Suboxone.
At my six-monthly checkup at my local hospital here in Spain there was a replacement doctor and since he was young I thought he might be willing to hear why I was not taking spiriva and steroids. He confirmed that a person with severe COPD MUST use these medicines. But - I objected - they do not cure, they’re only supposed to make you feel a little better and have nasty adverse effects.
Cause of low DLCO and drop in it from test 1 to test 1? I am currently on tiotropium bromide and salmeterol/fluticasone propionate. My reason for posting this is one doc is pessimistic and the other highly optimistic.
Thank you.
Spiriva® HandiHaler® (tiotropium bromide inhalation powder) has a maximum duration of action of about 36 hours. To be safe, you would want to be off the medicine for 48 to 72 hours before the spirometry. It would have been preferable, but not mandatory to do the pulmonary function tests (PFTs) at the time the diagnosis of chronic lung disease was made especially if the diagnosis was unequivocal. The other important question would be, “Why 3 CT scans, presumably of your lungs, in 16 months?
Hi Ryan,
Since you have so much knowledge about benzos, I have some questions. I have been on 1 mg. Ativan, twice a day, for panic and anxiety disorder for a little over a year. I am in therapy as well and I would like to wean off the Ativan soon.
serotogenic activity of the effexor may have easily contributed to this new anxiety disorder. It is also possible that nicotinic and/or muscarinic acetylcholine receptor function was modified (semi-permanently). In any case, try taking diphenhydramine (Benadryl, 25mg) about two hours before you'd normally expect the sweating to be at its worst. If you have accidently created a preliminary serotonin syndrome, have your doctor prescribe .
I have to agree with Eagle. Don't forget-- it isn't just about which receptors and how much/how little stimulation, but also the 'where' question. all medications will have different patterns of passing through the 'blood brain barrier', including some variability between patients in that effect. Plus, the effects of the ligands at their receptors goes beyond simply agonism and antagonism and their respective effects on electric currents.
Myasthenia Gravis (MG) is a rare autoimmune neuromuscular disease and the hallmark of this disease is muscle weakness that increases during periods of activity and improves after periods of rest. You may function normally sometimes and another time experience loss of strength.
In more than half the people who develop MG, their first signs and symptoms involve eye problems such as drooping of one or both eyelids (ptosis) or double vision (diplopia).
what happens is the lack of hormone keeps the body from producing LSL receptors and these are receptors that help remove the bad cholesterol from the body. When the number of the receptors decrease, LSL accumulates in the bloodstream which then causes the increase in your LDL and total cholesterol levels.
This can cause hardening of the arteries and of course eventually lead to heart attack.
Paxil is an antidepressant that blocks the enzyme that breaks down serotonin and targets serotonin to only certain receptors while bypassing others, allowing serotonin to wash longer in the receptors. Xanax is a benzodiazepine, an anti-anxiety and anti-seizure medication that targets GABA receptors. Benzos act only for a short time, some longer, some shorter, while antidepressants work all day while you're on them.
A macular hole itself will not cause pain as the retina does not have pain receptors like the skin. However worry, anxiety, and eye strain from the blurred vision and the eyes trying to work together is a frequent cause of eye strain and headaches especially if associated with visual tasks like reading and using computer.
The pleasure and pain receptors are very similar to each other some peoples bodies confuse them which sounds like your case. Dr. Drew who hosts the tv show 16 and pregnant, Teen mom and Celeb Rehab and the radio show Loveline has talked about this condition on his radio show. You can call into the loveline show and ask this question he can give you the full answer as he is a medical dr.
ssris target serotonin receptors, while snris target both serotonin and norepinephrine receptors. Your post is a little confusing -- did you taper off the Zoloft, or go off cold turkey, or switch to Lexapro, or are you on both Zoloft and Lexapro and now Cymbalta? Going off any of these meds abruptly, even if you switch to another, can trigger a withdrawal, which is why I'm asking.
Pain has receptors that respond and send the signal to the brain. It is said that over time, any pain that is not treated, begins to hurt more severe just because those receptors get over stimulated. Its like you body turns up the volume so you will hear it. Smoking keeps a pereson from healing as fast as they normally would otherwise. It is keeping our O2 levels from reaching their optimal place. As far as increased pain??
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