thalidomide optical isomers

ScienceDaily (Feb. 29, 2008) — Thalidomide, a drug blamed in the 1950s for causing birth defects, is now showing promise as a safe and effective treatment for women with recurrent ovarian cancer, according to a study led by a University of Minnesota Cancer Center researcher. -------------------------------------------------------------------------------- Levi Downs, Jr., M.D.

” The study compared the effectiveness and safety of the combination of thalidomide and topotecan, a chemotherapy often used for ovarian cancer, versus topotecan alone for treatment of recurrent epithelial ovarian cancer in patients who had received prior treatment. Epithelial ovarian cancer is a disease in which cancer cells form in the tissue that covers the ovary.

I have noticed that the levothyroxine has a sodium atom, heavier molar wieght and different structural formula. Isomers are known not to function like the parent compound. So why levothyroxine and not thyroxine in thyroid meds?

t want to start a new thread NEW YORK FEB 28, 2008 (Reuters Health) - The addition of thalidomide to topotecan appears to improve treatment response rates of recurrent epithelial ovarian carcinoma, according to the results of a phase II trial. Because both agents have antiangiogenic properties, the combination of the two might be more effective than topotecan alone, Dr. Levi S. Downs Jr., of the University of Minnesota, Minneapolis and associates speculated.

Someone said that Topotecan worked better when combined with thalidomide -- don't know much more about it than that, although when I have chemo again (when the Arimidex doesn't hold my counts steady anymore) they are threatening me with topotecan next.

Peripheral neuropathy has been seen in association with the following antibiotics metronidazole, nitrofurantoin, thalidomide and isoniazid. What are your neurological symptoms and has a physician correctly attributed them to sulfa drugs? There is no known peripheral neuropathy with the use of cephalexim, particularly short-term use. You can also check with the pharmacist.

thalidomide used in the past was thought safe.

m asking because in my whole life, i have never had a registered optician or any of the staff in a optical shop talk about optical center or do anything to make sure the center of the lens is over the center of my eye (unless you are referring to PD when making the lenses).

Anyone ever been dx with optical migraines (with visual disturbances)????? I Also have a LOT of dizziness and headaches(which I don't consider horrible migraine like but there you know) ! Can this be linked to thyroid issues???

Right now I am invloved in developing artifical vision for those whose vision is affected because of damge in optical nerves.I am trying to replace the damged ones with nano optical fibers.All I need is a good tutorial or a description of how important the optical nerves are, how and where are they connected and how does the brain identifies color. If you can help me with the following, it will be great. my mail I.

She went back to the hospital where doctors did many tests and MRIs and they diagnosed her with optical neuritis. They said that it could be of the first symptoms of MS. She's been getting a lot medication, but so far no results at all. She can't work, or go anywhere by herself. I am devastated and don't know how to help her at this point. She is coming to the US next week and i hope there is something doctors can do her here. Please, any advice will be greatly appreciated.

I have a history of optical migrains. I'd have one to two a year. But lately I've been getting 2-3 a week. I don't know what is causing them. I had mentioned it to my opthamologist but she didn't seem it was anything to worry about. In fact she took me off Betoptic drops. I had been seeing a different Opthamologist for years but because of the long wait to get in to see him, I switched doctors. I was suffering "dry" eye a year ago and now it has returned, also.

Hi, this morning I was using my lighted magnified mirror for a few minutes and while doing so I experience a zigzag line in my right eye which lasted for a minute, if that. I had this happen before back in the '90's. I believe this is called an optical migrain....do you think the light could have had something to do with the zigzag experience. Also, two years ago I had a vetrious detachment (spelling?) .... both eyes within a month of each other.

my dad is blind for the past 13 years AION-damage to optical nerve im willing to try anything any help?

OCT (optical coherent tomography) uses optical resonance not magnetic resonance so there is no radiation produced.

The only thing I can think of would be nerve ending damage which can happen while having treatment. Ask your doctor about that. I had it and it is not nice.

It is very difficult to treat, but current therapies include steroids, vitamins, cryosurgery, thalidomide and UVB light. If staphylococcus or other infection is present, then antibiotics may be needed. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor. I sincerely hope that helps.

I had a HIV 1 & 2 SALIVARY TEST and result came back as NEGATIVE. In the report, it was also mentioned that HIV OPTICAL DENSITY = 0.035 and in the corner it is mentioned < 0.280. My question is what is HIV optical density? what are those values. If the result is negative the value should be zero instead of 0.035 right? somebody who have knowledge about this, pls clear my doubt. Thank you!

Just to be on the safe side. You never know... Thalidomide was once considered safe too, but the result was catastrophic!

I was just wondering if Optical Migraines are related to MS in some way? Lately, I have had quite a few of them with the most recent being late yesterday afternoon. It seems that the Optical Migrain affects my left eye. I have a lesion on my right temporal lobe. When I went to bed last night I was having stabbing pain in the area of this lesion. Then, this morning I woke up and my right ear is muffled and kind of roaring.

I went from 20mg Celexa, to 10mg of Lexapro. Celexa has two isomers, one of which is more potent (the S isomer, thus "escitalopram" instead of "arcitalopram.) (r)citalopram has actually been shown to blunt the effects of escitalopram, and that's half of Celexa. So theoretically, taking just the (s) isomer has greater antidepressant activity. You would think 10mg of Lexapro equates to 20mg Celexa, but this isn't the case.

Fundus examination showed regressed choroidal neovasuclar membrane in right eye and scar in left eye. He was advised Fundus fluorescein angiography and optical coherence tomography. Optical cohdrence tomography showed flattened pigment epithelial detachment, resolution of neorosensory detachment, scarring in subfoveal choroidal neovascular with membrane appearing more compact and decreasein cystoid macular edema in right eye.

A related discussion, <a href="/posts/Eye-Care/optical-nerves/show/1809966">optical nerves</a> was started.

P1101 has only a predominant single positional isomer connecting the PEG molecule on the protein, compared with 8 to 14 isomers found in the two other pegylated-interferon drugs, respectively. Less frequent dosage should also mean a lower end cost and better compliance for the patient.

I've had servere dry eyes and a stye in my eye (duct) for 15yrs, and not one doctor or eye doctor has mentioned the option of opening my tear ducts or removing the stye. This discussion is related to <a href="/posts/Eye-Care/Optical-Migrains/show/864618">Optical Migrains</a>.

Thalidomide optical isomers

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