no tenofovir is not toxic, since adefovir was a failed drug for both hiv and hbv, drug makers tried to make a lot of disnformation and delay approval of tenofovir as long as possible.
to do this they took data from hiv carriers which are mainly drug addicts and drug addicts have destroied bodies, destroied immune system and organs already, no need for hiv or tenofovir to have any damage.
you have to be very clear on this: hiv use of tenofovir is not to be considered because hiv damages kidneys too, on hbv trials kidney toxicity is no issue since only 1% developped toxicity and lowering tenofovir dose resolve this and tenofovir is still very active on hbv.unfortunately there is no research on optimal dose of tenofovir on hbv without sides (tenofovir is produced by gilead and they wanted to push use of hespera and probably hiden tenofovir from 2001...
hbv has no symptoms, you may even be dying and feel nothing
tenofovir improves kideys function especially tenofovir+telbivudine in those with kidneys function.
Cipla
Form Packing (Max Retail Price)
TENOHEP tab
300 mg x 10's (623 INR)
Manufacturer Cadila
Form Packing (Max Retail Price)
TENTIDE tab
300 mg x 30's (2990 INR)
Manufacturer: Ranbaxy (Super speciality)
TAVIN tab
300 mg x 30's (1300 INR)
Manufacturer: Emcure (ARV)
Form Packing (Max Retail Price)
TENOF film-coated tab
300 mg x 10's (400 INR)
300 mg x 30's (1200 INR)
Manufacturer: Hetero HC (GenX)
CMX157, a novel lipid acyclic nucleoside phosphonate, “is up to 60-fold more active against HBV and more than 200-fold more active against all major HIV subtypes in vitro” compared with Viread (tenofovir disoproxil fumarate [DF], Gilead Sciences), according to the release. In a phase 1 clinical trial among healthy volunteers, CMX157 showed a favorable safety, tolerability and drug distribution profile.
what about the Italian study that you mentioned regarding half dose of Tenofovir ?
i was notice that the other nuc's used also in hiv (including the fail one), have a bigger dose in hiv then in hbv but thnofovir has the same dose and I was wandering why.
Do Tenofovir pills prevent infection after exposure?If so how long does it have to be after possible exposure?
//www.hivandhepatitis.com/hiv-treatment/experimental-hiv-drugs/3439-gilead-starts-phase-2-trial-of-tenofovir-pro-drug-gs-7340
My guess is: since Viread's patent will expire in 2-3 years, Gilead is trying to come up with a new drug (Well, sort of 'new'). And Agenix is competing with them.
P.S. I had some training in medicinal chemistry.
Association of Higher Plasma Vitamin D Binding Protein and Lower Free Calcitriol Levels with Tenofovir Disoproxil Fumarate Use and Plasma and Intracellular Tenofovir Pharmacokinetics: Cause of a Functional Vitamin D Deficiency?
"The finding of a 26% increase in vitamin D binding protein and a 42% decrease in free 1,25-OH(2)D between the lowest and highest quintiles of plasma tenofovir has not been previously reported.
checking tenofovir trials on hbv only (no hiv coinfection) kidney problems are in less than 1% patients and i haven't found tx discontinuation because of kidney problems.
hbv has no mutations at all under tenofovir tx and i think we can find data from some patients using tenofovir for more than 3 years even if not on trial about this.
entecavir mono has only 1.2% resistance but has several hbv mutations anyway altough only 1.2% has resistance to entecavir.
Members the first line oral anti viral for hepatitis b is tenofovir and according to doctor it is long life use. My question are 1) what is the efficacy and safety of tenofovir for says 10years or 15 years or 20years ? 2) what is the longest years of taking tenofovir that we have on record now?
There is a new version of Tenofovir in trials that is supposedly 200 times more potent than the TDF that is out now, boosting intracellular concentration, thus reducing any harmful renal effects:
http://www.chimerix.com/therapeutic-programs/category/cmx157/
https://docs.google.com/viewer?url=http%3A%2F%2Fwww.ihlpress.com%2Fpdf%2520files%2Fresistance08_presentations%2F06_Lanier_website.
So I cannot answer all your questions, especially about the safety of Truvada during pregnancy, however I am sure you can find more information on that topics, especially from experiences of HIV mothers. Many recent studies have indicated that Tenofovir (Viread) is safe throughout pregnancy and even suitable during breastfeeding.
This multicenter analysis included 104 HIV/HBV coinfected patients treated with ART regimens containing tenofovir. Again, most (about 90%) were men, the age range was similar, and about 60% were white; about two-thirds were HBeAg positive at baseline.
The investigators measured HBsAg levels at baseline, month 6, and then annually; the median duration of follow-up was 56 months (range 8-97 months). HBsAg clearance is generally considered a cure, though "occult: or hidden HBV may remain.
i really dont understand why use of truvada which is simply tenofovir plus ftc in one pill, tenofovir is the most potent drug against hbv replication and has no resistance so truvada has meaning as a business way to make money from patients with only side effects added to patients, truvada is more toxic on kidneys than tenofovir monotherapy
the only thing that may justify your doctor is the need to suppress hbv very fast in weeks instead of a couple of months but 151000iu/ml maybe suppressed in
no hbvdna is a goldstandard test, hiv rna detects who knows what, hiv has never been isolated
the indications of the producers of hiv tests say "this cant be used to determine an hiv infection"
look what nobels and biologists have to say about this fraud....do not waste your time on hiv, documentary "the house of numbers"
http://www.youtube.com/results?
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