You are correct that Truvada is a combination of tenofovir and emtricitabine, and is generally prescribed for patients with HIV. Being a HBV forum, most of us know very little about Truvada except that it is prescribed off-label for HBV by some doctors, and that it is recommended for HBV patients who develop resistance to Tenofovir.
Unfortunately, in 2002 when your wife first started with Lamivudine, antiviral treatment was still somewhat new and probably didn't fully understand what resistance means (and sadly some still don't). And in 2002, Adefovir was approved for treating HepB. Lamivudine has has a poor resistance profile. We know that now but can't turn back the clock.
Now, I am NOT a doctor. But I read that Telbivudine is okay to use during a pregnancy. So ask your wife doctor about that option.
Tenofovir is usually given at the start of third trimester, so you have to ask you doctor why he/she recommends an immediate start. However, many women do have exposure to Tenofovir throughout their pregnancy and generally it is safe. Some head size and bone mineral density issues in the newborn are noted. So it is very much a benefit and risk exercise when deciding to take Tenofovir before the recommended third trimester.
//www.infohep.
also telbivudine is looking for patients because another failure due to high rates of mutants and failure, telbivudine is also among the most unsafe for all patients due to sides
tenofovir is the only one totally safe for pregnancy, no resistance and most potent.once started it is good to continue tenofovir after birth.
be aware that with hbeag positive and high hbvdna your baby can get infected because vaccine fails with hbeag positive.
hbsag relapsed and it is obvious hbsag was too high when you stopped tdf, only hbsag less than 100iu/ml have chances to clear
Generally, Tenofovir is recommended throughout pregnancy, even during breastfeeding.
http://www.medscape.com/viewarticle/807416_6
"Treatment With Tenofovir
Although TDF has been used in HIV or HIV/HBV coinfected mothers, little data exist for mothers with HBV monoinfection. A recent case series study evaluated HBeAg-positive mothers with HBV DNA > 7 log10 copies/mL who received TDF 300 mg/d at the third trimester.
My doctors are trying to convince me to take Tenofovir in the last trimester of my pregnancy. I'm really debating on if I should or not because of some of the side effects. I know this should be the last of my worries but I'm wondering if anyone taking Tenofovir has had the buffalo hump side effect. Any suggestions would help.
http://www.uptodate.com/contents/hepatitis-b-and-pregnancy#H231281766. However, "no resistance whatsoever" is even better than "low resistance"; so no problem there.
Below is a not so good news about possible resistance of hbv against tenofovir in previously entecavir resistant patient. But this could just be an isolated case.
http://www.ncbi.nlm.nih.
any drug has sides but you have to be mart to understand who develops sides, on the contraru you are taking drugs that make damage in your situation, Lyvomin is a useless drug and has no indication on hbv
vitamin B can have sides and in the wrong dose can make liver damage and death...i guess tenofovir cannot kill, so what do you think vitamin B is a killing drug?
checking tenofovir trials on hbv only (no hiv coinfection) kidney problems are in less than 1% patients and i haven't found tx discontinuation because of kidney problems.
hbv has no mutations at all under tenofovir tx and i think we can find data from some patients using tenofovir for more than 3 years even if not on trial about this.
entecavir mono has only 1.2% resistance but has several hbv mutations anyway altough only 1.2% has resistance to entecavir.
tenofovir to make hbeag negative and hbvdna undetactable so that vaccine has almost 0% chances to fail
tenofovir is also good therapy for you with no resistance and 16% eradication at 2-3 years, check also hbvdna pcr and look for an expert liver specialist (there are very few really expert and most ignorant)
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