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Recent Highlights and Developments
Ongoing Phase II study of ARB-1467 evaluating two doses of ARB-1467 (0.2 mg/kg and 0.4 mg/kg) in HBV infected patients.
Preclinical combination data presented at the 5th Antiviral Drugs Research and Development Conference showing additive anti-HBV activity when combining AB-423 (core protein/capsid assembly inhibitor) with entecavir or interferon.
t smoke, do exercise, am thin). My doctor put me on a diuretic, Tekturna and Bystolic, and within a week I had completely lost my sense of taste! Anyone else experienced this? I'm wondering if it's a side effect that will wear off if I just stick it out. The combination seems to be working well to lower my bp and hr but I'm losing weight (a bad thing) and really, really miss food!
New Results from Phase II ARB-1467 Multi-Dosing Study In September 2016, Arbutus reported single dose ARB-1467 results for Cohorts 1 (0.2mg/kg) and 2 (0.4 mg/kg) and multiple dose results from Cohort 1 (Cohorts 1 and 2 enrolled HBeAg- patients). Today Arbutus is reporting multiple dose results from Cohort 2, which show a significant reduction in HBsAg. In both Cohort 1 and Cohort 2, an additive, step-wise reduction in HBsAg was observed with each dose.
Long history incoming:
I started getting mild headaches when I was 19. Nothing too imposing, just constantly there. Fast forward seven years and now I have migraines as well. At the peak, I was getting them 4-6 days a week. Fast forward another five years; I'm 32 and the migraines have gone down in frequency (but how, I don't know) and the headaches are still daily. I have experienced a long list of different symptoms, but I don't know how or if they are connected.
These are the ACE drugs and the ARB drugs. The best,in my opinion is the ARB drug Losartan, invented 1990, approved 1995, sold about 2000 and out of patent 2010 (therefore inexpensive). This drug blocks angiotensin varients from attach to the cells walls of the vascular system and cause vasoconstriction. Dose is generally from 25mg to 100 mg a day. Over 100 mg doesn't help much more. They prescribe once a day, but you can break up the dose into two pills a day.
I would encourage you to stay on this drug and if your cardiologist for some reason ever wants to take you off it, to make sure that he or she is aware of all the studies discussing ARB therapy and aortic root shrinkage. Please educate yourself on this - exceptionally important. I'm happy to answer any questions if you send me a private message.
Click on my screenname and look at my old posts about ARB and aortic aneurysm. ARBs (like telmisartan) are drugs that have been shown to stop aortic dilatation in MFS patients because it reduces the signaling that causes the aortic dilatation. I believe this is the same signaling that causes myopia in MFS, so if you halt the signaling with ARBs, you might halt increases in myopia just like you halt increases in aortic size.
Lisinpril can cause a chronic cough and you should stop this medication to see how the cough changes. It may be replaced with valsartan or candesartan which do not usually cause this side effect. The verapamil usually does not cause this side effect. This may not be related to your medications, and chronic cough or ' bronchial asthma' may actually be cardiac in nature ( e.g. CHF). Make sure your physician takes this other consideration into account.
Like ARB-1467, which is currently in Phase 2 clinical trials with chronic HBV patients, ARB-1740 can inhibit HBsAg production even from integrated HBV and utilizes lipid nanoparticle (LNP) technology to deliver siRNA to the infected liver. In vivo, ARB-1740 is up to 10-fold more potent than ARB-1467, resulting in 2.5 log10 serum HBsAg reduction at 7 days after a single 0.3 mg/
kg dose in a hydrodynamic injection mouse model of HBV.
The combination therapy with ARB and beta-blockade may provide more effective and safe protection to slow down and even reduce the aortic root diameter than sole beta-blockade in patients with MFS.
.....Isn't the conclusion dual therapy is considered more safe and efective than just BB? Also, the test is associated with MFS and not all triple A is so related. The most common cause of aortic aneurysms is arteriosclerosis. At least 80% of aortic aneurysms are from arteriosclerosis.
Blood pressure today-108 / 60. I do low impact exercises in the water, tai chi, and walking with in my mobility limits, and eat Heart Healthy. Don't drink or smoke, and limit caffeine tremendously. I will be going through another echogram soon to determine if the dilatation numbers have changed from 6 years ago. I am 53 and managed to NOT take any drugs dues to drug allergies in regards to the Elhers Danlos syndrome Type 3 hypermobility.
2. It is ok to take both an ACE and ARB and there have been some trials using both for blood pressure management. We just have to be very careful and watch your kidney function because both medications can affect the kidney funtion so make sure your physician checks your kidney function 1-2 weeks after being on both medications.
Hope this helps.
For some insight angiotensin converting enzyme (ACE) inhibitors and the angiotensin receptor blocker (ARB) drugs both affect the renin-angiotensin hormonal system which helps regulate blood pressure.
Hope this is the information you are looking for, if not you are welcome to followup with another post. Thanks for the question and take care.
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