I ended up in the ER where they took off 50 cc of fluid. Three days later 75 cc were taken off and a cortisone shot was given. The swelling eventually subsided. The very curious thing about this is that my sister had exactly the same experience with Synvisc -- second shot (not the first) reacted with pain and swelling and had to have fluid drained. Now, my doctor is suggesting Orthovisc. injections - 1 each week for 3 weeks. Am I in danger of the same reaction that I had with Synvisc?
t help but think it will be most interesting to see the data relative to success rates in the CC vs non-CC population after the release of Telaprevir.
desrt:
Especially agree with "suspect we'll find the predictive factor of race is simply a function of the distribution 'C' and 'T' alleles in the population." I think your posts above are dead-on; like the way you think!
I've searched the web and here and no really good answer. I'm taking a Sonata about 3 or 4 oclock in the morning. It does cause some jitters next day. Now I've started Sam-e and a Super Beta Complex and the Jitters are unbearable. I take some Xanax and it helps some. I can't take much and still function.
The question is ... Is it the Sam-e or the Super B Complex causing the extreme jitters or anxiety?
Thus, although CC patients may not achieve higher SVR rates with boceprevir combination therapy vs pegIFN/RBV alone for 48 weeks, the advantage is that the majority qualify for shorter therapy (28 weeks). Boceprevir substantially improved SVR rates for patients with the CT and TT genotypes: SVR rates were 71% and 59% for CT and TT genotype patients in the BOC + PR48 arm and 65% and 55% for those in the BOC + PR-RGT arm, respectively.
454 patients were evaluated. The frequency of IL28B-type was CC=29%,CT=53%,TT=18%. CC-type was strongly associated with RVR (CC=51%,CT=42% and TT=7%,P=0.0001) as well as higher rates of week-8 and 12 response. CC-type was associated with SVR in both arms (70% and 69%,P =1.0). In patients with RVR, SVR was high and IL28B-type was not associated with SVR (84%/87%/86%, for CC/CT/TT, P=0.92).
another option is to get your doctor to prescribe something specifically for insomnia such as ambien, sonata or trazodone. discuss over the counter options with him such as benadryl and others available.
lastly, its great to hear YOU know what works best for YOU. don't discount that.
Anyway, when I took it to the pharmacy, all of the medications was controlled substances, percocet, sonata, and diclofenac. I was shcoked but the pharmacist tech already scanned it and I trust the FNP. I always go to this same pharmacy and never had a problem filling my prescriptions and my disabled problem. The pharmacist was even willing to fill the diclofenac at the time. I decline and told her I would pick them up Monday when all 3 were ready and I this didn't fill right.
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Influence of IL28B Polymorphism on Response to Telaprevir
In a retrospective analysis of the ADVANCE trial, patients with the IL28B CC genotype achieved higher SVR rates vs patients with the CT or TT genotypes. Indeed, in the T12PR arm, patients with the CC genotype achieved an SVR rate of 90% vs only 71% and 73% of patients with the CT and TT genotypes, respectively.
Influence of IL28B Polymorphism on Response to Telaprevir
In a retrospective analysis of the ADVANCE trial, patients with the IL28B CC genotype achieved higher SVR rates vs patients with the CT or TT genotypes. Indeed, in the T12PR arm, patients with the CC genotype achieved an SVR rate of 90% vs only 71% and 73% of patients with the CT and TT genotypes, respectively.
Interim Results Show High SVR Rates With Either 12 or 24 Weeks of Telaprevir Plus Peginterferon/Ribavirin in Patients With HCV Genotype 1 and IL28B CC Genotype
Among patients who completed 12 weeks of triple therapy, 100% SVR12 rate among patients who continued to receive peginterferon/ribavirin through 24 weeks vs 89% SVR4 rate among patients who stopped all therapy at 12 weeks.
In QUEST-1, SVR12 rates among patients treated with simeprevir with IL28B genotype variations were 94 percent for the CC allele, 76 percent for the CT allele, and 65 percent for the TT allele. In QUEST-2, SVR12 rates among patients treated with simeprevir with IL28B genotype variations were 96 percent for the CC allele, 80 percent for the CT allele, and 58 percent for the TT allele.
Anyway I have been with this replaced doctor for a yr and a half, I had been explaining to him that 2 vicaprofen in a 24 hour period is not sufficient he by the way had taken me off the motrin and changed my Xanax to Ativan. I also have been on sonata 10 mg for all these yrs. I was given a urine test which is pretty normal, before I took it I told him that there would prob. not be hydrocodone in it as we had been discussing that I needed more pain relief.
http://www.natap.org/2011/HCV/101111_02.htm
This give cirrotics a 79% chance. Amazing how I can find so many different % for cirrhotics
Clinical trials have shown that a telaprevir based regimen is more effective than standard treatment in all genotype-1 patient types, including those with advanced liver disease such as cirrhosis. The addition of telaprevir cleared the virus in almost twice as many previously untreated patients (79% vs. 46%, p<0.
The nurse told me that it is good that I waited for the Telaprivir study (twice a day dosing vs. every 8 hrs). She told me with my phenotype tt, the regular txt with interferon probably would have not worked. Can someone please explain the phenotype tt to me and if anyone who did txt with Telaprivir had the phenotype tt? Thanks you.
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