Paresthesias, also sometimes referred to as dysesthesias, means abnormal sensation of the skin, like prickling, burning, tingling, pins and needles,
numbness, tightness, wetness, shock-like sensations, even itching. In MS it is due to damage to the CNS, specifically demyelination. In the limbs, it is due to lesions on the spinal cord. It is one of the most difficult MS symptoms to treat.