No teratogenic
effects were observed in rats, rabbits,
and monkeys at oral doses approximately 6, 4,
and 3 times, respectively, the MHD, although maternal toxicity was evident at these dose levels. When the dose was increased to about 9 times the MHD or higher in pregnant rats, a dose-dependent increase in the number of fetuses with ventricular septal defects was observed. This effect did not occur in rabbits or monkeys.