Rosiglitazone, an old diabetes drug is active on hbsag lowering and synergistic with nucs and interferon.these are the drugs to study not stupid nucs that acts on hbvdna only making mutations.
on the contrary studies on these cheap and generic durgs are not funded by drug makers, on the contrary we see stupid doctors without trials or studies saying now that these drugs can make liver damage while it is the opposite.
org/wiki/Thiazolidinedione
this drug is same family as Rosiglitazone (Avandia) which has been foud active on hbsag and hbvdna, question is does TZD lower hbsag since decrease of hbsag inibits cancer growth too and if lowered to und eradicate hbv?
Ben Weintraub, director of research, Wolters Kluwer inThought
We expect that 2011 will be the year for novel oral anticoagulants, as the FDA gets over its hesitation in approving Xarelto (rivaroxaban) and we begin to get mature data for apixaban, edoxaban, and others. Physicians in Europe and the U.S. will begin to replace heparin with Xarelto and Pradaxa (dabigatran).
On this basis, the EC50 (50% effective concentration) of rosiglitazone was calculated as 9.8 mcM. Rosiglitazone also suppressed replication of HBV strains with core promoter and/or precore mutations in addition to the wild type strain.
"In this study, it was suggested that the replication of HBV was inhibited by rosiglitazone," the researchers concluded. "The mechanism is uncertain and is being investigated now."
12/4/09
References
T Bader, B Korba, and M Bronze.
Is the pitting edema progressive? Are you on pioglitazone? or rosiglitazone? Answers to these questions would further help.
Evangelin posted about this youtube video. "Sugar , the bitter truth"
It is a long video , but what I did not know before watching it is that
High Fructose Corn Syrup metabolically is as bad as alcohol for the liver.
The majority of processed foods we find in the supermarket have High Fructose
Corn Syrup which can majorly effect obesity and fatty liver.
Studies of these medications—including metformin, rosiglitazone, and pioglitazone—are being sponsored by the National Institutes of Health and should answer the question of whether these medications are beneficial in NASH.
I recommend you research for yourself on teh FDA website, the EMEA (european FDA) website as well as runnign a google on it. There are many un-nerving entries on teh internet about this drug. However, it is good to do your own research and then se this information to discuss with your cardiologist or EP. Best wishes.
The newer antidiabetic medications make the body more sensitive to insulin and may help reduce liver injury in patients with NASH. Studies of these medications—including metformin, rosiglitazone, and pioglitazone—are being sponsored by the National Institutes of Health and should answer the question of whether these medications are beneficial in NASH."
So NASH is a very serious medical condition which requires expert medical care for the best prognosis.
In Hong Kong, the risk fo your partner being infected with HIV is certainly lower than if she were an IV drug user. How much lower is hard to say. Thus again., your risk of infection is lower, and probably far lower than 1 in a million.
about 60 percent of patients in the insulin-sensitizing group took rosiglitazone or Avandia. He said there was no increased risk of heart attacks among patients in this group".
Diabetics with stable chest pain account for about 40 percent of all U.S. patients who get angioplasty, according to Wachovia analyst Larry Biegelsen, who said the findings could cut U.S. procedures by 3 percent.
Been doing a bit of research. on www.ivf.com/pcotreat.html and have found that it may be an option for me to have "medicines used....for the treatment of adult onset diabetes... These medications have been shown to reverse the endocrine abnormalities seen with PCOS within two or three months.....We have seen pregnancies result in less than two months in women who concieved in their very first ovulatory menstrual cycle.
There is increasing evidence that this endocrine abnormality can be reversed by treatment with widely available standard medications which are leading medicines used in this country for the treatment of adult onset diabetes, metformin (Glucophage 500 or 850 mg three times per day or 1000mg twice daily with meals), pioglitazone (Actos 15-30 mg once a day), rosiglitazone (Avandia 4-8 mg once daily) or a combination of these medications.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Minor Interaction Be watchful with this combination
Diazoxide (Hyperstat, Proglycem) interacts with BRANCHED-CHAIN AMINO ACIDS
Branched-chain amino acids are used to help make proteins in the body.
If such measures are not adequate, anti-diabetes drugs such as metformin (Glucophage), pioglitazone (Actos), and rosiglitazone (Avandia) may also be used to increase insulin sensitivity, which may help reduce fat accumulation in the liver. While these medications have not yet been studied extensively in people with hepatitis C, there is data suggesting that they are associated with reduced ALT and improved liver histology in HCV negative patients with non-alcoholic fatty liver disease.
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