I have fatigue that began with severe, intractable (non-
MS) vertigo. Then the vertigo doubled with the
MS. I started out on 200mg
and went to 300mg. I could fucntion, really had to becasue of a major medical thing in my family. But, I seriously overdid it and crashed hard (bed for 2 weeks).
You have to pace yourself, even though you feel like you can do so much. The crash can undo all of Provigil's help.