Niaspan mechanism of action
Common Questions and Answers about Niaspan mechanism of action
niaspan
I am not physically restricted - I walk 1 mile or more day and do 10 minutes of other light exercises most days. My BP runs under 120/80 most of the time. I understand carvedilol helps prevent stiffening of the heart muscle and can help restore LV function to some degree. How specially, so it do this? What is the biochemical mechanism?
I know that you're questioning Niaspan vs. liver. I wanted to also share with you a side effect of Niaspan is gout. If you never had it before, and start to more than likely it's the Niaspan that caused it. My husband was on Niaspan for a a couple of yrs. well, for the last yr. before discontinuing it, he kept getting flare-ups of gout. He started to get it more often than not.
I have been taking 1000 mg Niaspan for six years to treat genetically high Lipoprotein(a). Now my physician wants to stop the Niaspan and begin a very small dose of Crestor. His reason is due to a recent study indicating Niaspan as a risk of causing bleeding and/or infection problems. I have already had one bad experience with another statin, Advicor, that resulted in me having permanent lymphedema in my ankles and legs. Now I am unsure about Niaspan.
I have searched the literature and have not found any articles linking Niaspan with any form of cancer. Niaspan is just niacin, one of the B vitamins, and as far as I can tell, is not cancerous in the dose given in Niaspan. As for your other question whether a five year study can demonstrate a drug-cancer connection, it would depend partly on the study design. The strength of the association between cause (the drug) and effect (cancer) would depend on how the evidence is gathered.
I was also told by my pharmicist that Plavix has a generic coming out in July. Ask your pharmicist if there is a generic of Niaspan due out any time soon.
And as Flycaster has stated, with the Niacin there is a flushing feeling also. It only bothered me if I didn't take an aspirin just before taking the niacin. My doctor told me about that.
The mechanism of action of Campral® (acamprosate calcium) Delayed-Release Tablets in maintenance of alcohol abstinence is not completely understood. Originally, several neurotransmitter systems, including GABA, were investigated for a possible role in Campral's mechanism of action. However, recent evidence suggests Campral's main interaction is with the glutamate system. Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition.
http://www.nasdaq.
In an effort to increase my HDL, I take Niaspan & Zocor.....Recently my MD upped the Zocor from 5mgl. to 10mgl....
Last couple weeks, have had more trouble sleeping, usually waking up after a dream (not nightmares, but somewhat vivid dreams)...I've checked out few sites, & saw that statins can cause sleep problems....Have others here had sleep problems while taking a statin?........
CRP does not always indicate your arteries are inflamed , the inflammation could be from one of a number of sources. I'm on Niaspan because its one of the few treatments that can raise HDL while lowering LDL and increasing LDL particle size. If you are worried about CRP, the statins are really good at lowering this number, independently of what they do to your chol. numbers.
Plavix has a unique mechanism of action by blocking the amplification of platelet activation by released ADP, and often used with aspirin to prevent the risk of clots for the first year after DES implant. Plavix and aspirin have different mechanism of action to prevent clots. After a year, plavix is usually discontinue as the risk for clots is decreased, and aspirin is continued long term. The risk of a clot is about 3%.
Well, it depends on what kind of medication you are on. I am taking Niaspan for cholestoral and these are the side effects of it. When your body have enough of these vitamins, it flushes out of body like this. It is advised by proffessionals to take an aspirin half an hour before taking Niaspan to avoid this flush. In my case, I simply stopped taking Niaspan and seek alternative from my doctor. It is always good to see doctor in such cases. I hope this is helpful to you.
You may want to try the Niacin (Niaspan is Niacin), it will definitely increase your HDL. I'm told that if you take it with aspirin it lessens the effect of the facial flushing. Also, a fatty liver is common in overweight individuals, the doctors I volunteer with have no issues prescribing cholesterol meds to individuals with fatty livers. It is very important, however, that you get your blood panel checked every 6 months or so to watch out for changes in your liver function.
Call your doctor if your blood pressure is still 168/110. Blood pressure of 110 can cause stroke. My husband had blood pressure of 157/100 and was sent home from work and told to go to bed and relax until he could be seen by his doctor. He works at a college where there are nurses to take blood pressure. You need to have heart testing done to see why the sudden change and if anything happened to your heart to be bringing on these symptoms.
My MD & I have been trying for about 5 years now to raise my HDL (I have family history w/father dying of heart attack at 48) .Niaspan only raised it nominally, & now he wants to try Crestor.....Are statins good for raising HDL?...If one can keep their LDL down low enough say under 80, is HDL still significant?....Except for HDL, my other numbers are good...I'm non-smoker, & ideal weight, & active.....
If you have diabetes or higher than normal blood sugar levels, you should carefully check your blood sugar levels, especially during the first few months of NIASPAN and during any change in your dose. Report any changes in your blood sugar levels to your health care professional.
Hypothyroid (high TSH) has a huge effect on cholesterol levels. When your TSH gets back to normal your triglicerides should improve also.
You could also ask for an A1C blood test.
HIV is transmitted by;
Unprotected penetrative anal and/or vaginal sex
Sharing works with other IV drug users
Mother to child
You never had an exposure.
Potassium is a chemical element and it is part of the electrolyte that should be in balance with other lytes to adequately conduct an electrical impulse that originates with the sinus node in the right atrium. The mechanism of action is not completely understood, but what is when a voltage (unit of potential for conduction) and electrolyte there will conduction and passage of electrical impluses.
http://www.medscape.com/viewarticle/578705
Ribavirin improves early responses to peginterferon through improved interferon signaling.
Gastroenterology. 2010 Jul;139
The therapeutic mechanisms of ribavirin for hepatitis C are unclear. Microarray analyses have shown that ribavirin increases induction of interferon-stimulated genes. We evaluated viral kinetics, serum cytokine expression, and viral mutagenesis during early stages of peginterferon therapy with and without ribavirin.
I take Niaspan which is an extended release form of niacin. Niaspan will decrease your LDL and triglycerides and increase your HDL.
I would not change your niacin dose w/o talking to your doctor about it. Decreasing the dosage could decrease your HDL.
I was taking 1500 mg of Niaspan at one point for about 7 months My HDL was around 42-44 for 3 measurements. It then drop to 32. My cardiologist immediately bumped my Nispan dosage to 2000 mg and my HDL went to 50 a year later.
Seeing an orthodontist is advised.
"Mechanism of Action Oxomemazine, a phenothiazine derivative, is a sedating antihistamine"
The above information is about all I could find on this drug. If it is used in the US, I have no idea what label it's under.
Even if I had been able to find more information, I am not qualified to tell you to either stop or start or change any medications. You need to speak with your doctor or chemist for an answer to your question.
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