neupogen growth factor

If you are on high levels of Nupegon (like for stem cell collections for stem cell transplant) you may want to limit your drinking.

Oh, I I get it. I just associated growth factor with growth hormone. I didn't look at the link. My bad - makes perfect sense now.

It is a long lasting human growth factor and is taken approximately every 3 weeks.The side effects are about the same as neupogen but happen much less frequently. You can think of it as a pegylated neupogen.

This shows the dosing information for neupogen while on hcv tx. According to this information the neupogen should be stopped or taken less often if the anc is over 1000. Mine was at 6500 after five injections, and my doc tells me to keep taking the neupogen. Granulocyte Stimulating Colony Factor Criteria for Use for Hepatitis C Treatment-Related Neutropenia VHA Pharmacy Benefits Management Strategic Healthcare Group and Medical Advisory Panel Prepared by: K. Tortorice, PharmD BCPS , H.

to compare the effectiveness rate of sustained viral response (SVR) in patients with Pegylated Interferon dose modification and in patients treated by using granulocyte colony-stimulating factor G-CSF-filgrastim. (Neupogen). Study enrolled 47 patients with chronic active hepatitis C, aged 23-64. (38 male and 9 female). All patients had HCV genotype 1b. Significant neurtopenia (ANC<750 mm3) and severe neurtopenia (ANC<500 mm3) developed in 41 of 47 patients (87%).

s the ANC that should be the determining factor as to whether intervention with Neupogen or dose reduction is necessary. ANC does bounce around but in the case of a steady decline with no upswings Neupogen is necessary. If the ANC drops below 500 most doctors get concerned but some aggressive hepa's will continue treatment even when it drops below 500. However, Neupogen should be considered when the ANC reaches continues to drop. Different doctors have different thresholds.

218-221) IMHO, the above cautions, coupled with higher SVR-rates in the setting of growth factor use for hemotologic complications, provides reason for the medical community to continue administration even when risks are low: " Granulocyte colony-stimulating factor for hepatitis C therapy-associated neutropenia: systematic review and economic evaluation. " Author: Tandon, P.; Doucette, K.; Fassbender, K.; Vandermeer, B.; Durec, T.; Dryden, D. M.; Add.Author / Editor: Tandon, P.

Hi Diana...Your Mum could have Neupogen or Neulasta shots to boost the white cells if they are down. I've had Neupogen a couple of times when my white cells were low, but it does make the bones sore, so I just eat lots of fresh fruit and veggies, and don't seem to have any problem in staying on schedule for my chemo. I hope your Mum continues to do well, and she gets great results at the end of it all. Best wishes and hugs...Helen...

To optimise my prospects I would prefer to avoid dose reduction, at least for the intial 12 week period so have been making enquiries re growth factors (rescue drugs). The are generally unavailable here unless prepared to pay for them privately. Have been trying to cost what a ceiling amount might be for a 12 week period to see if I can organise sufficient funds. Neupogen in prepared syringes are sold in packs of 10 - $1504 for 3000mcg/.5ml shots and $2407 for 480mcg/.5ml shots.

He was probably referring to Neupogen which is also known Filgrastim which is a human granulocyte colony-stimulating factor (G-CSF). Basically, it encourages the growth of the white blood cels that the Interferon depletes with treatment. For more information go to neupogen.com The riba, similarly, depletes red blood cell. If your hemoglobin gets low they might also prescribe Procrit for that. Go to procrit.com to learn about that stuff.

The growth factor(Neup) would have no bearing on the immune system It is only a bone marrow enhancement for production of white cells.Not taking it would have no effect on tx. other than possibly your ANC would be low...which in itself when doing HCV tx, has been shown to not have much impact on infection ..

I've had 3 surgeries for breast cancer. Lymph nodes were 8 out of 12 positive but the last 3 were microscopic. Can Neupogen be used in place of Taxol? I've read that Neupogen attackes the cancer cells more with better results. Whn my cells were tested they found that the good cells were really attacking the bad ones. I'm just afraid that reg chemo will mess this all up and I won't have anymore good cells to help fight. What is the best thin to do?

thank you Answer Hi, Neupogen acts as a granulocyte-colony-stimulating factor and is known to cause thrombocytopenia. Basically neupogen can enhance the phagocytic ('cell eating') activities of neutrophilic leukocytes (white blood cells), including activity directed at autologous platelets. Neupogen can stimulate white blood cells to the point that they can attack the platelets in the blood, causing the low platelet count.

If your white blood cells and anc get too low they either lower you interferon or use neupogen (grow stimulating factor) injections to raise the count. Hopefully they won't go low enough that they have to do either. neupogen is definitely preferred over dose reduction in my opinion but of course this would depend on your doctor's management of the situation.

I have heard of much worse before anyone started growth factor drugs. My tests look pretty similar and I don not feel well at all, so I empathize with you completely, though I am not sure exactly of the correlation between the numbers from the vampires with how one feels :) My labs improved somewhat this week. There are now about the same place they have been for months. I wonder if the fact that I had the last test from a different laboratory had something to do with the drops???

last blood mine stabilized at 3500 after reduced dosage, still high but not crazy high. Neupogen can stimulate cancer cell growth, you don't want more then you need. http://www.pbm.va.gov/Clinical%20Guidance/Criteria%20For%20Use/GCSF%20Criteria%20for%20Use%20for%20Hepatitis%20C,%20Criteria%20for%20Use.pdf "Titrate filgrastim dose to achieve ANC 500-1000/mm3.

thank you Answer Hi, Neupogen acts as a granulocyte-colony-stimulating factor and is known to cause thrombocytopenia. Basically neupogen can enhance the phagocytic ('cell eating') activities of neutrophilic leukocytes (white blood cells), including activity directed at autologous platelets. Neupogen can stimulate white blood cells to the point that they can attack the platelets in the blood, causing the low platelet count.

s better to boost the ANC with the Neulasta or Neupogen. I think the nurse has mixed up the response time for Procrit for boosting hgb with the response time for the neulasta or neupogen, which are nearly instantaneous in someone who responds to them. I think there may be another factor that the nurse didn't mention, which is low platelets. If both low neutrophils and low platelets are the issue, skipping one interferon shot and starting back with reduced interferon is the proper plan.

m currently on Procrit (and Neupogen) and it basically helps boost RBC growth, i take it weekly, mostly to help with hemolytic anemia caused by the Interferon and Riba for treatment. the Procrit stings a little when i inject weekly but really no side effects as of yet and i've been on it for about i think 10 weeks weekly, can't remember. but the side effects aren't nearly as bad as the other ones.

Not having insurance is a factor as Neupogen is expensive--but call the pharmaceutical company and try and get them to PAY!! Try anything!! Hope this info helps and you have a blessed day today...

Neupogen growth factor

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