neupogen and leukocytosis

//www.rxlist.com/neupogen-drug.htm "in cancer patients receiving NEUPOGEN® as an adjunct to myelosuppressive chemotherapy‚ it is recommended‚ to avoid the potential risks of excessive leukocytosis‚ that NEUPOGEN® therapy be discontinued if the ANC surpasses 10‚000/mm3 after the chemotherapy-induced ANC nadir has occurred. Doses of NEUPOGEN® that increase the ANC beyond 10‚000/mm3 may not result in any additional clinical benefit.

A WBC count of 11.0–17.0x109/L cells would be considered mild to moderate leukocytosis. Eating, physical activity and stress can cause an increased WBC count. See your doctor again and look for the cause of your persistant brain infections.

The white blood cells (hopefully number verified with a duplicate test to make sure accurate) being at that level is cnsidered slight leukocytosis according to and old manual of lab diagnostics tests I have which is a second edition by Frances Fischbach. Did they do a differential white blood cell count? Leukocytosis is typically owing to an elevation of just one typ of white blood cell.

i hav got total leukocytes count 14,400/cmm. and in remarks its written neutrophilc leukocytosis. i want to know what does it indicate. has anyone suffered from this ? i hav an appointment soon but want to know from u guyz before. also in morphology its written mild hypochromia/anisocytosis. any information from you people is really appreciated.

My 5yr old daughter has had very enlarged lymph nodes for over 6mths. At first, it was a 3-4cm cervical node on the right side. She now has a 1cm node on the left side, just above the clavicle. She has ongoing belly pain. She has had numerous blood test. Always showing lymphocytosis. Her lymp count is now up to 62% (normal is up to 40%). When they did a CT scan due to belly pain, they found "numeroud messentary and retroperitneal lymph nodes".

I found this one look question and answer thing from a cancer patient to a doctor about neupogen causing low platelets. My doctor and others I have spoken to have said they never heard of this. Anyone have more info about it? this is the only thing I can find that mentions neupogen and low platelets, perhaps neup just doesn't effect platelets.

thank you Answer Hi, Neupogen acts as a granulocyte-colony-stimulating factor and is known to cause thrombocytopenia. Basically neupogen can enhance the phagocytic ('cell eating') activities of neutrophilic leukocytes (white blood cells), including activity directed at autologous platelets. Neupogen can stimulate white blood cells to the point that they can attack the platelets in the blood, causing the low platelet count.

the only medications i take is a blood pressure/water pill and cholestorol medications.... what can cause this and does anyone on this forum have the same situation...

frijole, thanks for the feedback. I've read various things and I have been getting hit with this and that thing lately. I can't afford to have it impact my work any more than it already is so I need to weight it all out. Jim...possibly low because of the infection but it won't matter why they're low, just that they're low. However, if the levels go up as I shake off the infection, I'll hold off on the neupogen.

Next time I try treatment I'm going to suggest to my doctor to prescribe neupogen and procrit before I start to get the counts up. Mine have always dropped into the low range. I found especially the neupogen made me feel rough after I was already well into treatment and didn't do a whole lot. Why don't doctors prescribe it before treatment? Would there be a downside to that?

I got a call from my doctor 3 months into my hep c treatment that I had no white blood cells and had to get a shot of neupogen immediately! I was on neupogen for 7 months, and I had all kinds of side effects from it, especially on my left upper back and shoulder (it felt as if maggots were gnawing at my bones). I had pains everywhere which made me have panic attacks that I was having a stroke, not the case. Every time I showed up at the doctor telling him I was dying he said I was fine.

I asked if I could use the rescue drug(s) instead of reducing but was told I had to reduce and could add Neupogen (rescue drug) beginning tomorrow. I picked up the neupogen tonight and didn't realize I'd have to inject it. Should I inject in the fatty part of my stomach or does it matter where I inject. I won't be able to talk to anyone at the clinic until Monday and need to inject tomorrow. Going for repeat labs Tuesday and will be able to talk with the Dr at that time.

I drop stuff all the time with my rt hand and arm. I was doing some research and found that the instruments used in my procedure where not recommended with someone who has Leukocytosis. The PEEK cage. My Leukocytosis has been Dx as Idiopathic, as 2 bone marrow Bx's have not been able to show anything. Wondering if my body may be rejecting the material in the PEEK or causing excessive bone growth.

I'm on week 12 SOC and began 2x/week neupogen at week 8 when the ANC went down to 325 (cells/uL). Since the ANC responded well (5100 cells/uL), I'm hoping to reduce this to 1x/week and monitor each week. My platelet count also steadily declined until the start of the neupogen (119 thousand/uL) and climbed gradually back within range (152 thousand/uL). I don't know if the neupogen resulted in this increase or it is bouncing around on its own as mentioned above.

Hi, i have leukocytosis and for some reason my doctors cant figure out why that is. (I always have recurrent UTIs) One month from finding out the same, im now having swollen lymph nodes, pinching feeling all over my body, short breath and feeling faint. (Collapsed when kneeling to pray the rosary). Now i am very paranoid and very worried that it might be a blood disorder. The last time i had a blood smear, it showed enlarged platelets. What's wrong with me?

31 treatment shots into it, I've taken 12 Neupogen shots off and on. Now we're trying 1 a week for the past 4 weeks. The outcome of this round will be found out Aug 09. I'm positive about cuz previous test shows it does what it's supposed to do. Finding that Goldilocks spot of shots needed for a relatively stable WBC count is the deal. Physically, reaction has been zero to 2 or 3. Often it gives me a slight boost. Hopefully your daughter will have a similar experience.

Ok so I've been on cephalaxin for 10 days, went off for 1 day, and now infection is back so skin doctor wants me to do another 10 days. Just got blood test results, neutophils are around 600, so doc doesn't want me to take shot until I have more blood work done. I am ten weeks into treatment, and I don't understand why neupogen isn't an option. I go for my twelve week test in two weeks and am already nervous about that.

I take neupogen on Thursday, peg on Friday and procit on Monday. I let all the drugs come to room temperature and lately inject in my belly because my legs are so sore. I also inject very slowly. I have not experienced the burning sensation and hope I can avoid that "joy.

Hi! I'm sorry to hear you're not feeling well... I'll assume you're not on any medication that would elevate your levels, anything like that. Leukocytosis [raised white count] can be due to anything and everything. In your body you have different types of white cells.

5 and she probably did suggest Neupogen. Sounds to me like he needs both and pretty darn quickly. She seems to be of the opinion that a transfusion will be needed for the low hemoglobin. At 7.3 he must really be dragging. Mine has never gotten that low but a lot of folks are experiencing this on the triple. So how is this going to work out? You said the GI is not going to reduce ribavirin doseage. I think the insurance company will get in the middle of this -- they sure did with me.

3 so I did the neupogen on Wednesday morning and did my interferon on Friday morning as usual. From what I can tell the neupogen works fast and then leaves my system just as fast. I let the neupogen sit out for about 15 to 20 minutes and don’t shake it b/c it’s syrupy compared to the interferon and the bubbles that come from shaking won’t leave so you’ll have to throw away that vial.

I just read that a lot of people try NOT to take Neupogen unless it is a necessity due to sx. I am on Neupogen and I take it 3 times a week and have been taking it for 8 mos. now. Does anyone know exactly why people/anyone would want to NOT take Neupogen? Your answers may provide some insight for me and my sx's.

I was supposed to do a shot tuesday, however got bloodwork done today and anc is 620, Doc says to take neupogen tonight (I did, the neupogen is 300mcg, im ~130lbs) and get more bloodwork done on thursday, and then he'll call friday with whether or not to take the shot or not. So here I am, waiting, again. Arggg!

Neupogen and leukocytosis

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