There is no conclusive evidence of alternate day dosage being as therapeutic as the initial dose or even the maintenance dose of
XR 150mg per day. What we do know at this stage is that the dose of
XR/XL 150mg every other day is recommended and appropriate for those who cannot eliminate the drug in time, such as in liver diseases. But with other conditions being normal, we are not sure about the effectiveness of 150mg alternate day dosage over a longer period than needed for a taper off.