A 12 years old girl had a blood transfusion with hiv blood, she took PEP( tenofovir, emtricitabine, ritonavir-boosted darunavir (subsequently changed to lopinavir) and raltegravir) after 24 hours and had these PEP for three months. This girl also has cssr5 dna which is a dna that hard to infect hiv. After 8 months, she had a negative result on HIV RNA and HIV ag/ab test. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226216/).
At day 22, i took raltegravir from the box but im not sure whether i drank the pill with the water or not. Normally, I remember the pills that I drank through glass of water but i cannot remember this time whether i drank this pill with glass of water or not but i counted pills and i concluded that their numbers are as expected.
I searched couple of papers and i concluded not to double the dose in the case of i used that pill.
combining emtricitabine and tenofovir from the NRTI class, and raltegravir, from the integrase inhibitor class. There ARE alternative drugs available and possibly in Thailand they use lamivudine in place of raltegravir. I am definitely NOT a chemist, so I can't tell you for sure if the combination you're taking is appropriate. You should discuss your concerns with the doctor who prescribed PEP or a pharmacist/chemist. I wish you the best.
Hi everyone, I have take a PEP treatment for 25 days, which included Lopinavir&Ritrnonavir & Truvada.
I have had diarrhea, anxiety, sleepless nights, depression, numbness in hands and legs, while using these
medications. Its been a week i stopped the medication and all my HIV tests have been negative so far.
Has anyone read the news that came out yesterday about hpv treatment with the Lopinavir drug?
It shows some promising results so I'd like to get anyone's take on this.
This study has to do with an HIV retroviral medication, if used on HPV patients, it might cure them. The drug is already produced, called lopinavir, however we need to make a topical version that is more potent:
http://bodywart.com/hpv-news/lopinavir-destroy-hpv-infected-cells/
You might also want to look into a antiviral drug recently produced by MIT called DRACO. It sounds very promising but needs to be tested on actual humans.
1 - would PEP be effective even if the source has a high viral load?
2 - After the 28 days, can I drink alcohol?
Thank you very much in advance, I am quite distressed about it.
I started PEP 2 hrs later (truvada, norvir, raltegravir, and preszita), my initial results are negative. I do not know the viral load of the patient yet, i can only pray that it is low. I know odds are 0.3% but that doesnt settle my fears, i am young and want to live a happy healthy life with KIDS! DR. please tell me if you have honstly heard of any cases like mine that have converted. I am in awe and feel like my life is totally over and ruined.
Zidovudine and Lamivudine Tablets ,Lopinavir/RitonavirOral Solution .i want to know ,will it work?how much percent will i avoid being infected?thank you all!
So, I am at the 15th day of my pep regime and have been strictly adhering to the program till today. I have been taking lopinavir ritonavir along with tenofovir. I am taking 2pills twice for the first one and one pill once a day for tenofovir. Today my bottle of rito/lopi finished after I took my first dose. I went to the doc clinic which was closed and he says i can only get the meds tomorrow.
I am currently taking truvada and isentress (raltegravir) is this enough I couldn't get my prescription for dolutegravir filled...is this pep enough?
11,12am), I take hiv block drugs from doctor, these drugs are Tenofovir Disoproxil Fumarate Tablets , Aluvia (Lopinavir and Ritonavir Tablets) and Lamivudine Tablets. I have take these drugs for 28 days (until 2013.10.8),at 2013.10.9(1 day after taking drugs) , I have take a HIV Duo or Combo (4th generation) test and the result is negative .
so, I want to know
1. Could these drugs delay the hiv window period , so that the combo tese was not correct?
2.
1-My partner tested Negative(Antigen/ Antibody) on 22 days post exposure
2-Thinking that i might be developing facial Lipodystrophy (slight facial fat loss under cheek bones). I cant tell if my face was like this before the treatment or it is just an illusion.
What can i do to really know if i developed some lipodystrophy ? any test u can advise about?
m confused on the prescriptions given to me I have a 7 day dose of raltegravir and dolutegravir...thought it was supposed to be 28 days?
This is known. Are there any similar action in the protease inhibitor, such as Kaletra (lopinavir) for example?
Have you ever thought about that?
I read - sometimes laugh. Simvastatin, vitamin D, which the Chinese poeben, mythical new drugs, masturbation with measurements of the level of HBsAg, and other nonsense....
I appreciate your blunt response. I was prescribed Truvada + raltegravir (PEP) but could not obtain raltegravir in Europe. To be fair, I called the US PEP hotline who told me that I could take Truvada as PEP as there are no studies that prove it’s ineffective, so I didn’t start it without advice from the US HIV experts. I agree my anxiety is an issue but I legitimately was seeking an answer.
Anyways I rushed to the hospital and was put on PEP at a maximum of 3 hours post exposure (truvada and raltegravir). I have taken the pills without missing any doses. At 3 weeks post exposure the lymph nodes in my neck swelled up slightly and I felt a tiny bit feverish. Checking my temperature rectally though revealed it was always in the 37s. These strange symptoms lasted only 2 days...could this be ARS?
I actually went to the clinic, got PEP (truvada 200mg and Raltegravir 400mg), also done hiv prick test which was negative. Dr was helpful and explained everything for me. He also said best thing is as u guys suggest, ask him test but also if he is clear 6 weeks back also, but that also depends on trust.
On my side i don't wanna embarrass him as twice he told me not to worry.
In the following day, I finally could find a very good hospital with a specialized area for HIV treatment, and the doctor was quite surprised that they had given me just a Truvada. She added a Isentress (raltegravir) to my Pep treatment. But I could realized that she was quite worried because I had had only Truvada in the begining of my treatment and in the very deadline edge.
I am taking Truvada and Raltegravir. Yesterday, (3 days after exposure and 2 days on PEP) I had protected sex with a female partner (I, the insertive male) and when I ejaculated I am afraid some spilled off the base of the condom.
If I began PEP 24 hours after possible exposure and had protected sex with someone else on Day 2 of PEP, could I have biologically put them at risk for HIV if by any chance the ejaculate spilled off the condom?
What is my overall risk of acquiring HIV, taking in consideration all that I have described above?.
Thank you very much in advance.
I started PEP 2 hrs later (truvada, norvir, raltegravir, and preszita), my initial results are negative. I do not know the viral load of the patient yet, i can only pray that it is low. I know odds are 0.3% but that doesnt settle my fears, i am young and want to live a happy healthy life with KIDS! DR. please tell me if you have honstly heard of any cases like mine that have converted. I am in awe and feel like my life is totally over and ruined.
//www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/ucm309863.htm
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Here is another:
The Effect of Telaprevir on the Pharmacokinetics of Buprenorphine in Volunteers on Stable Buprenorphine/Naloxone Maintenance Therapy
Co-administration of telaprevir did not increase withdrawal symptom frequency and there were no serious adverse events reported during or after completion of telaprevir co-administration.
I presume you had anal sex, because oral is not a risk.
HIV is only diagnosed from a test so all your details and questions have no answers.
Since you have passed 28 days, you can just take a 4th gen test for a conclusive result and all the details you mention which are just question marks will become irrelevant.
However, after 2013, three-drug regimen consisting of a nucleoside reverse-transcriptase inhibitor (NTRI), (tenofovir plus emtricitabine), along with a third drug, either an integrase strand transfer inhibitor, raltegravir or a boosted protease inhibitor, darunavir/ritonavir is recommended for PEP.
Ideally, NTRI is an important component of the regimen because if HIV infects a cell, it first attaches to and fuses with the host cell.
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