Hi everyone, I have take a PEP treatment for 25 days, which included Lopinavir&Ritrnonavir & Truvada.
I have had diarrhea, anxiety, sleepless nights, depression, numbness in hands and legs, while using these
medications. Its been a week i stopped the medication and all my HIV tests have been negative so far.
Has anyone read the news that came out yesterday about hpv treatment with the Lopinavir drug?
It shows some promising results so I'd like to get anyone's take on this.
This study has to do with an HIV retroviral medication, if used on HPV patients, it might cure them. The drug is already produced, called lopinavir, however we need to make a topical version that is more potent:
http://bodywart.com/hpv-news/lopinavir-destroy-hpv-infected-cells/
You might also want to look into a antiviral drug recently produced by MIT called DRACO. It sounds very promising but needs to be tested on actual humans.
1 - would PEP be effective even if the source has a high viral load?
2 - After the 28 days, can I drink alcohol?
Thank you very much in advance, I am quite distressed about it.
Zidovudine and Lamivudine Tablets ,Lopinavir/RitonavirOral Solution .i want to know ,will it work?how much percent will i avoid being infected?thank you all!
So, I am at the 15th day of my pep regime and have been strictly adhering to the program till today. I have been taking lopinavir ritonavir along with tenofovir. I am taking 2pills twice for the first one and one pill once a day for tenofovir. Today my bottle of rito/lopi finished after I took my first dose. I went to the doc clinic which was closed and he says i can only get the meds tomorrow.
11,12am), I take hiv block drugs from doctor, these drugs are Tenofovir Disoproxil Fumarate Tablets , Aluvia (Lopinavir and Ritonavir Tablets) and Lamivudine Tablets. I have take these drugs for 28 days (until 2013.10.8),at 2013.10.9(1 day after taking drugs) , I have take a HIV Duo or Combo (4th generation) test and the result is negative .
so, I want to know
1. Could these drugs delay the hiv window period , so that the combo tese was not correct?
2.
1-My partner tested Negative(Antigen/ Antibody) on 22 days post exposure
2-Thinking that i might be developing facial Lipodystrophy (slight facial fat loss under cheek bones). I cant tell if my face was like this before the treatment or it is just an illusion.
What can i do to really know if i developed some lipodystrophy ? any test u can advise about?
This is known. Are there any similar action in the protease inhibitor, such as Kaletra (lopinavir) for example?
Have you ever thought about that?
I read - sometimes laugh. Simvastatin, vitamin D, which the Chinese poeben, mythical new drugs, masturbation with measurements of the level of HBsAg, and other nonsense....
028,Hemoglobin F=0.000,Hemoglobinopathy- Negative by HPLC methodology. Hemoglobin =134 AND 130, Hematocrit=0.39,,RBC =4.3, iRON 14, tibc 44, Transferritin saturation 0.32, Immunoglobulin M 0.31, Immunoglobulin G 11.92, Immunoglobulin A 3.62, ESR 33,
HAPTOGLOBIN 2.38, Bilurubin total 2, Lactate Dehydrogenase 163, RECTIC RELATIVE 1.3, RECTIC ABSOLUTE 57, FERRITIN 138, TSH 0.
What is my overall risk of acquiring HIV, taking in consideration all that I have described above?.
Thank you very much in advance.
A 12 years old girl had a blood transfusion with hiv blood, she took PEP( tenofovir, emtricitabine, ritonavir-boosted darunavir (subsequently changed to lopinavir) and raltegravir) after 24 hours and had these PEP for three months. This girl also has cssr5 dna which is a dna that hard to infect hiv. After 8 months, she had a negative result on HIV RNA and HIV ag/ab test. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226216/).
000,Hemoglobinopathy- Negative by HPLC methodology. Hemoglobin =134 AND 130, Hematocrit=0.39,,RBC =4.3, iRON 14, tibc 44, Transferritin saturation 0.32, Immunoglobulin M 0.31, Immunoglobulin G 11.92, Immunoglobulin A 3.62, ESR 33,
HAPTOGLOBIN 2.38, Bilurubin total 2, Lactate Dehydrogenase 163, RECTIC RELATIVE 1.3, RECTIC ABSOLUTE 57, FERRITIN 138, TSH 0.
was 5 points high, good cholest was 5 points low. Bun/creatine ratio was a little low, but the numbers themselves were avg. HPLC was 5.7 (5.6% was the top range for normal). Bacteria was classified as rare. Since then, I've had a few good days in terms of bowel movements, but experience discomfort (not pain really) below the ribs (upper middle) on both sides (sometimes more on the left side), lower back, and mid-back (though i think the mid-back is from lifting my daughter).
This paper btw seems very consistent with other similar studies, including those that show serum riba levels (via HPLC testing) help deterimine both RVR and SVR. Unfortunately HPLC testing for serum riba levels is not available except in trial situations, but if it were, then one could reasonably pre-dose and keep increasing the riba dose until a set serum riba level was met.
These 35 patients had urinary free cortisol determined by both HPLC and competitive binding methods. The efficacy of the HPLC assay using cortisol alone was equivalent to that of the competitive binding assay; 22 of 29 (76%) patients had increased cortisol. Cortisone also aided in the diagnosis; 25 of 29 (86%) had increased cortisone. Twenty-seven of the 29 (93%) patients had either both cortisone and cortisol (n = 19) or at least 1 of the 2 (n = 8) increased.
Treatment with PEG-IFN-alpha 2a, 180 ug/week and ribavirin 1000 mg/day was started, and lopinavir/r/3TC/tenofovir was continued. HCV RNA was cleared after 12 weeks and AST levels normalised. At month 13, still on PEG-IFN/ribavirin therapy, AST levels increased and HCV RNA became detectable. Genotyping showed HCV genotype-2. The patient admitted he had participated in one more ‘fist-@%* king’ party at month 11 in Berlin. The patient denied IVDU at any time.
For those too concerned about catching HPV(which most will do anyway), there's great news about the use of the lopinavir drug to cure HPV. What do you think, Dr. Handsfield?
Hi Swish,
Welcome to MedHelp's Pain Management Forum. I'm glad you found us and posted your question here.
As usual our Remar has offered some good information. UDT (urinary Drug Test) is a chemical science - either well or poorly understood by PMP. Chemistry was never my strong suit - and that's what UDTs are all about.
It depends on the type of UDT your PMP utilized.
Sorry again Teak Lamavudine (Lamavir) Stavudine (Stavir) and Kaletra
Lindahl mesured riba absorption through HPLC (high performance liquid chromatography) testing which is not available in this country, unless perhaps in some research labs. Unfortuantely, very little work here in this area which could potentially have salvaged many, many SVRs, but resources (money and white coats) are elsewhere, mostly with the PI's. I expect we will see some pre-dosing studies soon and maybe some enlightened clinicians will start demanding HPLC testing for their patients.
it sucks but it's not the end of the world. i do know how you feel as I felt the same way before.
Read other posts as there is A LOT of info here. However to help address your concerns, CELEBREX might help. Your doc probably won't just give it to you though. Lopinavir might also but probably even harder to get. In the meantime, build up your immunity and try Tagamet. It can't hurt. Get at least 20 minutes of sun exposure daily. Daily asprin might also help a little.
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