Hi everyone, I have take a PEP treatment for 25 days, which included Lopinavir&Ritrnonavir & Truvada.
I have had diarrhea, anxiety, sleepless nights, depression, numbness in hands and legs, while using these
medications. Its been a week i stopped the medication and all my HIV tests have been negative so far.
Has anyone read the news that came out yesterday about hpv treatment with the Lopinavir drug?
It shows some promising results so I'd like to get anyone's take on this.
This study has to do with an HIV retroviral medication, if used on HPV patients, it might cure them. The drug is already produced, called lopinavir, however we need to make a topical version that is more potent:
http://bodywart.com/hpv-news/lopinavir-destroy-hpv-infected-cells/
You might also want to look into a antiviral drug recently produced by MIT called DRACO. It sounds very promising but needs to be tested on actual humans.
1 - would PEP be effective even if the source has a high viral load?
2 - After the 28 days, can I drink alcohol?
Thank you very much in advance, I am quite distressed about it.
HBV replicating cells were treated with different dosages of Flavocoxid to determine the drug inhibitory concentrations (IC50). Treatment with Flavocoxid or ETV or with drugs combination started 3 hours after transfection and was renewed every other day for 5 days. Total HBV replicative intermediates, viral transcripts and cccDNA levels were evaluated in untreated and treated HepG2 cells by quantitative real-time PCR, Southern and Northern blots experiments.
Zidovudine and Lamivudine Tablets ,Lopinavir/RitonavirOral Solution .i want to know ,will it work?how much percent will i avoid being infected?thank you all!
So, I am at the 15th day of my pep regime and have been strictly adhering to the program till today. I have been taking lopinavir ritonavir along with tenofovir. I am taking 2pills twice for the first one and one pill once a day for tenofovir. Today my bottle of rito/lopi finished after I took my first dose. I went to the doc clinic which was closed and he says i can only get the meds tomorrow.
11,12am), I take hiv block drugs from doctor, these drugs are Tenofovir Disoproxil Fumarate Tablets , Aluvia (Lopinavir and Ritonavir Tablets) and Lamivudine Tablets. I have take these drugs for 28 days (until 2013.10.8),at 2013.10.9(1 day after taking drugs) , I have take a HIV Duo or Combo (4th generation) test and the result is negative .
so, I want to know
1. Could these drugs delay the hiv window period , so that the combo tese was not correct?
2.
1-My partner tested Negative(Antigen/ Antibody) on 22 days post exposure
2-Thinking that i might be developing facial Lipodystrophy (slight facial fat loss under cheek bones). I cant tell if my face was like this before the treatment or it is just an illusion.
What can i do to really know if i developed some lipodystrophy ? any test u can advise about?
This is known. Are there any similar action in the protease inhibitor, such as Kaletra (lopinavir) for example?
Have you ever thought about that?
I read - sometimes laugh. Simvastatin, vitamin D, which the Chinese poeben, mythical new drugs, masturbation with measurements of the level of HBsAg, and other nonsense....
What is my overall risk of acquiring HIV, taking in consideration all that I have described above?.
Thank you very much in advance.
efficacy ratio (CC50:IC50), which is sufficient for clinical development in HBV.
“We have almost three decades worth of experience in cyclosporine chemistry. Drawing upon this experience in structure-activity relationships, we have learned that relatively small and selective changes to the chemical structure of the cyclosporine backbone can have very dramatic consequences in pharmacology,” commented Dr. Foster.
Two compounds, proparacaine and chlorophyllide, were shown to reduce HBV levels 4- to 6-fold with an IC50 of 1 and 1.5 lM, respectively, and were selected for further study.
A 12 years old girl had a blood transfusion with hiv blood, she took PEP( tenofovir, emtricitabine, ritonavir-boosted darunavir (subsequently changed to lopinavir) and raltegravir) after 24 hours and had these PEP for three months. This girl also has cssr5 dna which is a dna that hard to infect hiv. After 8 months, she had a negative result on HIV RNA and HIV ag/ab test. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226216/).
In a biochemical assay, GS-461203 inhibited the polymerase activity of the recombinant NS5B from HCV genotypes 1b, 2a, 3a and 4a with IC50 values ranging from 0.7 to 2.6 M. GS-461203 is neither an inhibitor of human DNA and RNA polymerases nor an inhibitor of mitochondrial RNA polymerase.
Antiviral Activity
In HCV replicon assays, the EC50 values of ledipasvir against full-length replicons from genotypes 1a and 1b were 0.031 nM and 0.004 nM, respectively.
Treatment with PEG-IFN-alpha 2a, 180 ug/week and ribavirin 1000 mg/day was started, and lopinavir/r/3TC/tenofovir was continued. HCV RNA was cleared after 12 weeks and AST levels normalised. At month 13, still on PEG-IFN/ribavirin therapy, AST levels increased and HCV RNA became detectable. Genotyping showed HCV genotype-2. The patient admitted he had participated in one more ‘fist-@%* king’ party at month 11 in Berlin. The patient denied IVDU at any time.
For those too concerned about catching HPV(which most will do anyway), there's great news about the use of the lopinavir drug to cure HPV. What do you think, Dr. Handsfield?
Sorry again Teak Lamavudine (Lamavir) Stavudine (Stavir) and Kaletra
Importantly, CRV431 was shown to have the widest selective index of any known cyclophilin inhibitor, calculated by CC50/IC50 ratio. This optimized selective index may correlate with a best-in-class therapeutic index, and therefore, enhanced clinical utility against HBV.
it sucks but it's not the end of the world. i do know how you feel as I felt the same way before.
Read other posts as there is A LOT of info here. However to help address your concerns, CELEBREX might help. Your doc probably won't just give it to you though. Lopinavir might also but probably even harder to get. In the meantime, build up your immunity and try Tagamet. It can't hurt. Get at least 20 minutes of sun exposure daily. Daily asprin might also help a little.
My PEP course consists of 150/300mg of Lamivudine/Zidovudine (Zovilam) and 400mg/100mg of Lopinavir/Ritonavir (Kaletra) taken every 12 hours for 30 days. I have just taken my third dosage.
My concerns and questions:
1. The doctor in the ER told me that my risk of HIV infection is extremely low, but if I wanted to be safe I could agree to a PEP course, which I did. She also told me there were some side effects. My question is how low was my risk in terms of percentages or numbers?
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