I myself used to have lows when sleeping often enough to frighten me and my husband when I was taking
NPH. I switched to taking a 24-hour
insulin called
Lantus, and this solved the problem for me. So if he is not interested in switching to a pump, beautiful control without severe lows can be acheived with this newer-than-NPH insulin.
I agree with the previous postings that stress can cause lows, and of course being a newlywed is a stress, even though a GOOD stress.