Lantus mechanism of action
Common Questions and Answers about Lantus mechanism of action
lantus
I am not a physician, but the mom of a type one diabetic on the pump. I have not heard of this type of side effect from Lantus. I would suggest you talk to your endocrinologist and tell him, you problem, he might be able to switch you r insulin type or see there are other things causing you to have dry eyes. Several types of medications can cause that condition.
Hope this helps. Pleas let us know how it goes.
And yes, I agree that there is a peak in the action of Lantus somewhere between 4-5 hours, usually. Some people notice it more than others. I notice it a great deal and have to feed it when it happens. But it still is much better than the old NPH insulin with its horrible peak actions that could get dangerous.
And as for the sweats about a half hour after taking Lantus, there IS a slight peak action with Lantus, although this peak action for most people is several hours after taking the Lantus. In my case, I usually take my Lantus at about 6 am, and I notice a peak that causes my glucose levels to drop by about 8 am. This happens even if I have not taken any Novolog or eaten breakfast (sometimes I wait until I get to work to take Novolog and eat breakfast), so it has to be the Lantus peaking.
I am not physically restricted - I walk 1 mile or more day and do 10 minutes of other light exercises most days. My BP runs under 120/80 most of the time. I understand carvedilol helps prevent stiffening of the heart muscle and can help restore LV function to some degree. How specially, so it do this? What is the biochemical mechanism?
No, I am not aware of any people who have contacted us with any kind of resistance to Lantus. I do know that Lantus must be replaced at the end of a month on one bottle. The expiration date is really important, for near the end of the month, some of us find that it no longer crystallizes properly. Some people notice that when the Lantus bottle is about one month old, it doesn't work well. But if you just started the bottle, this is probably not the problem.
Have you searched this website for previous postings? There are many of them regarding the use of Lantus that you may find helpful. Check them out and also check for others responses to your post. I would most definitely speak to your endocrinologist after doing some research and I am certain that between the two of you can come up with a regime that works well for you.
Best of luck!
just found out my son has type 1, he was in the hospital for a week with out of control bs levels of over 500. he works on a sliding scale and carb count for his insulin and gets 15 mg of lantus everynight. i am still having alot of trouble with his high bs at night. i have that stupid fear of giving him to much insulin and then he gets lantus. i guess the ?
I agree with KevinHarney. NPH insulin is an older type of insulin, and it has a VERY noticeable "peak" action that happens in the middle of the day, around 3 pm. I grew up on NPH and really had to watch for mid-day lows. Most doctors nowadays use Lantus alone as the long-lasting insulin and have given up NPH altogether because of the scary lows that often happen when it peaks.
It would involve one daily injection of a long-acting insulin like Lantus, which has a flat action profile over 24 hours. And a shot of Humalog or Novolog before each meal. Doing this would minimise the carb/insulin mismatch when you skip a meal.
The basal/bolus regimen would give you more flexibility and better control. You may want to discuss this with your doctor.
I too have had a couple of bad low sugar episodes... But not from Lantus, but from mistaking my Humalog pen for my Lantus pen. They are not exactly easy to tell apart when you are tired (I take it at night). I was taking 16 units, so imagine the same of Humalog! Wow! Cram those glucose tabs!!!
On a pump now (or rather the pod) for the past couple days. Harder to goof up.
However, you may find that your fasting blood sugar becomes higher due to the dawn rise now being at the end of the lantus action. Alternatively, talk to you dr about using levemir. This is dosed morning and night and the dose can be different for morning and evening to target optimal blood sugars. There is also a new insulin called Tresiba. Many find that this gives very stable blood sugars with less risk of lows. You may also discuss this with your Dr.
my doctor had me start by removing only 1 unit of my morning dose of Lantus, and then that night I took 1 unit of Lantus. That meant that I was only 1 unit shy of my total for the day. Then I waited 2 days to see what the pattern would be (you could even wait longer to see what happens). Then I did the same procedure again, removing another unit from my morning dose of Lantus and adding it to my evening dose. And wait several days to see what happens in the mornings.
Now I am on the flexpen (great inivention) taking Regular and one shot of Lantus before bedtime. It all works! I am so sorry to hear that your wife has filed. If her reason(s) are because of the diabetes, she is so selfish. Being married to any diabetic, the partner is wise to learn and be there if needed. I am so sorry to hear this. It's not like we haave leprosy! NPH is a slower working insulin and starts workingabout 2 hours after injecting.
The mechanism of action of Campral® (acamprosate calcium) Delayed-Release Tablets in maintenance of alcohol abstinence is not completely understood. Originally, several neurotransmitter systems, including GABA, were investigated for a possible role in Campral's mechanism of action. However, recent evidence suggests Campral's main interaction is with the glutamate system. Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition.
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I believe that the older Lantus is just losing its crystallization ability and that I get a bit of a dump at that time of day when it is getting close to time to replace the bottle. I have experimented with my timing on the quick-acting insulin and strongly believe the dump is the Lantus. Try changing to a new bottle, and see if this solves the problem.
I would also never every recommend that he do something that would violate CFR regulations by concealing the fact he is taking Lantus with an insulin syringe. My own opinion is that use of Lantus together with Metformin, together with exercise and tight dietary control (and I mean tight) would not unduly hazard the general public.
If your husband is taking Lantus and Humalog or Novalog, he may want to talk to his endo about switching the time of the dose of Lantus. For people with night lows, taking the Lantus in the morning is the safest way to take this particular type of insulin, for it DOES have a slight peak action about 4 hours after injection, and for people taking it at night, the peak is while they sleep.
If I take it at bedtime, I find that getting control of dinnertime BG is very difficult - I have to use 3-4 x the normal dose of insulin to get on top of it until it is time to take the Lantus. Then, I have a perfect fasting and control one day and it starts slowly eroding so that in 3 days I am dealing with BG's in the 200's.
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