Ezetimibe was found to have a 50%inhibition conc of 25micromolar, while irbesartan, a commonly used angiotensin inhibitor to reduce blood pressure, was found to inhibit at 11.9 micromolar. Both compounds have similar MW, but irbesartan is given at up to 300mg per day, while exetimibe is dosed at 10mg. Thus the combination of 30fold higher approved dose and the double micromolar inhibition potency makes, in theory, irbesartan 60 fold more potent to inhibit Hbv entry.
m currently taking Irbesartan every morning and is now controlled well. I enjoy traveling in hot conditions, some days can be up to 39 degrees. Can my blood pressure medication stand such heat if I was to say just put it in my wallet? I'm always traveling to different places and don't always have access to a fridge or ice to take on hand. If not, are there any other heat resistance BP medication i can try?
Can you please advise if I am taking high blood pressure medication (irbesartan) and Altorvastatin for high cholesteron and I am also taking Tamoxafin for breast cancer (about to come off this drug), is it adviseable to take Leptin Cocoa for health weight loss or would this affect the medications?
very interesting trial, although on hbv ezetimibe might be weaker.for those not aware of ezetimibe studies
Ezetimibe blocks hepatitis B virus infection after virus uptake into
hepatocytes.
http://www.medhelp.org/posts/Hepatitis-B/Ezetimibe-blocks-hepatitis-B-virus-infection-after-virus-uptake-into-hepatocytes-/show/1868002
The efficacy of ezetimibe add-on with combination peginterferon plus ribavirin therapy in patients with HVC
http://astp.jst.go.
put me on lowest dose of Losartan and I got joint pain in my thumbs and then in a knee so I weaned myself off but my BP was very high (systolic) during visit. He puts me on Irbesartan, SAME class of drug, then goes on VACATION. It's the smallest dose and I took a corner of a pill yesterday, no pill today, BP is fine, I'm in PAIN. My thumbs hurt, my right foot and left knee, I don't feel well and then I read that all of this are side effects of this drug.
I am a male 70 years of age. I have been on 150mg Irbesartan and 5mg Amlodipine daily since October 2010. This controlled by BP within acceptable limits. Since late April, however, the systolic has risen to an average of around 150. My doctor wants me to add a beta blocker to the other medications. Since last October my heart rate was averaging below 60. Since late April it is averaging around 70.
my friend just started taking trandolapril 1mg and Irbesartan its only been a couple days but she feels awful
dizzy, heart palpatations, head ache and her blood pressure is still really high 190/110
should she just stick it out?
Hi, My doctor has diagnosed a mild calcification of the aortic valve and mild to moderate aortic regurgitation. I also have mild hypertension which is controlled with Irbesartan. I'm 50 and don't seem to have any symptoms but what can I expect and what can I do to improve my condition.
Call your pharmacist or your doctor and ask if this is a known side effect of the med you're on. Ask if stopping has any risks, and if not, it's a good idea to stop and see if that solves your problem. Sometimes you have to taper off some meds but unless your BP is so high you're about to drop dead from it, most BP problems depending on your age and how long the problem has existed can be fixed by changing diet and lifestyle.
Someone in my support group here is in a trial with Kaiser and taking SOC plus the Plough Shearing SI that has a number instead of a name. She's doing very well and will be done in 3 weeks.
boc trial is working good for me. I went in with a viral load of 13 million, in 2 weeks i had a viral load of 2 million. 1a . there are others here who have just about cleared. they will chime in.i will let you know next tuesday about results for 6 weeks. thats with n2 weeks of boc added.
Its been a couple years since I have been here. I did a trial in 2013 with someone that was dosing based on tsh and I eventually gave up. Now looking back I have discovered that I probably was not absorbing the medication. I also know that supplementing with iodine likely sabotaged any progress I was making since is causes tsh to rise in addition to tanking my iron. These are my observations based on the last two years of monthly labwork.
Personally, I take valsartan, but my friends have experienced similar success (or better) with candesartan, telmisartan, losartan (although this drug is surmountable and thus theoretically not the best one to take), irbesartan, and, for ACE inhibitors, perindopril.
Most trial exclude post-transplant patients. The only trial that would be conducted would be through transplant centers
Have you spoken to your transplant center? They would know about any clinical trials that they will be conducting that you would qualify for.
You will need to be under the care of a transplant center if you should make any changes to the drugs you are taking.
You can get the trial number from the informed consent and maybe send out a message to see who is in the same trial. I was in a trial with IFN, RBV, GS9451 and GS5885. Had to drop after 12 weeks due to viral load going back up as a result of resistance. This was my second attempt at tx - was a non responder the first time. Good luck and hope that you get UND and SVR.
Hi, Yes that is the one!. They are taking four subjects from this office for the study. Yes, Giddyup is a 1a. Our only hesitation this time (he did the infergen trial for Intermune) is starting the whole combo therapy again , been there done that twice already, and he was exhausted just on mainentance for a year and a half... we have about a week to decide. but they drew bloods yesterday to be sure he qualifies, and the nurse said this moring that his platelets were good...
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