Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
Is it possible that after taking gleevec for only two weeks WBC droped from 36.7 to 7? All other blood counts are also came back to normal range. Could doctor make mistake in diagnosis of CML? Maybe I should get seg second opinion?
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
After two weeks on 400mlg gleevec my WBC droped from 36.5 to 7.1. My doctor told to come for additional test in two weeks. Now my WBC is 1.3 and absolute neutrophils count is 0.04. I was told to stay home on antibiotics. How long it may take for my counts to clime back to safe range. And of course, I'm off gleevec right now. Does it seem that dose of 400mlg is too high for me.
Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
You might find he starts to be able to tolerate the pill. Gleevec is first choice for treating CML, and if he is doing good in every other way then encourage him that he is doing great.
I hope this helps you. I would be glad to help you with any other questions.
Is there a relationship between cancer and scleroderma? I am involved with a small scleroderma group and we have had about 11 deaths to cancer with scleroderma. My sister also had scleroderma and ended up with lung cancer. The doctor is talking about treatment if i get any closer to cancer.
I am not sure I am posting this in the correct place. I am not so good with the comp.
i get my heart checked every 2 weeks now and i am fine with the qt thing. i take the chemo pill called gleevec and have to force myself to eat so i dont get sick when i take it. how long will these withdrawel problems go on? i have xanax to take (1mg) but dont work to good. i should would appreciate any advice from any one on how to deal with these issues, family dr says its anxiety but i think its the withdrawels from the high dose of elavil.
//www.mayoclinic.org/diseases-conditions/scleroderma/symptoms-causes/syc-20351952 Scleroderma is group of rare diseases that involve the hardening and tightening of the skin and connective tissues and can involve the esophagus.
I would recommend calling your doctor about the difficulty swallowing. Let us know how you are doing.
It sounds like you're referring to scleroderma. It is a connective tissue disease that can cause the symptoms that you are describing.
One of the main treatments for scleroderma are corticosteroids (such as prednisone - that's what it's called here in the States, but not sure what it is called in Nigeria). There's no "cure" for scleroderma (that I know of anyway) - treatment of current symptoms and trying to keep new ones at bay are the usual course.
Are there any tests I should request?Also, I am wondering if I have Systematic Scleroderma. I do not have any skin issues at all. My hands are always cold;they do not change color or get painful. My right foot is always swollen on the top of my foot and 3 middle toes only. I have had this on and off for years and my GP doctor gave my a water pill to take. He thought I may have poor circulation in my leg.
I'm 18 and for a couple of years now my hands and feet, no matter what, are ice cold and normally pale blue in color. When I go outside my hands tense up, turn blue, and it hurts to move them and when they get warm again they turn a bright red. I researched this and found that is maybe something calls "Raynaud's phenomenom" which is a sort of syptom for scleroderma. My mother had scleroderma. Is raymaud's phenomenom what this problem is?
My father had Scleroderma, he felt like it started because he was exposed to agent orange in Vietnam. Is there a good chance I will get it too?
Yes, nucleolar pattern is seen in scleroderma and in CREST Syndrome which is a type of systemic scleroderma. The other possibility is systemic sclerosis, again quite related to scleroderma. The ESR will be high and RA factor may be positive.
Do discuss this with your doctor. Take care!
Anyways I know the inspire scleroderma site peeps talk about the GI effects of scleroderma all the time. Scleroderma is kind of rare and not everybody knows tons about it. There's a kind of sclero that has no skin involvement called sine scleroderma. Just an fyi.
ve read says that this means I will get scleroderma and I am freaking out! Does anyone with a nucleolar pattern have something other than scleroderma?
The nucleolar pattern is seen in scleroderma and in CREST Syndrome which is a type of systemic scleroderma. The other possibility is systemic sclerosis, again quite related to scleroderma. The ESR will be high and RA factor may be positive. Hence these two tests should be done. Please discuss with your doctor. Take care!
The medical advice given should not be considered a substitute for medical care provided by a doctor who can examine you.
The clinical relevance of autoantibodies in scleroderma.
"Anti-Scl 70 antibodies are highly specific for scleroderma and are seldom present in other diseases."
--Source: Sclero dot org
"The formation of autoantibodies against chromatin is the main feature of systemic lupus erythematosis (SLE)"
--Source: Triggers for anti-chromatin autoantibody production in SLE. LUPUS Dec.
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