Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
t want to see me, that fever was not from gleevec, and that I needed to monitor myself by myself by simply taken ibuprofen. This is what I did all last week and only this Monday he did a blood work.
For now, what can I do to help my body to build my immune system back? Any vitamins? I'll appriciate any advice.
I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
Anyways I know the inspire scleroderma site peeps talk about the GI effects of scleroderma all the time. Scleroderma is kind of rare and not everybody knows tons about it. There's a kind of sclero that has no skin involvement called sine scleroderma. Just an fyi.
Please google scleroderma and inspire. There is a sight that focuses on scleroderma. They have a very helpful and supportive group of folks.
Raynauds is often the first symptom of scleroderma. I don't have the exact list of symptoms you are describing and I am still in the catagory of undifferentiated connective tissue disease. But the symptoms you are describing especially the raynauds and "sunburnt skin feeling" and some others sound possibly suspicious.
Symptoms of CREST
By Mayo Clinic staff
While some varieties of scleroderma occur rapidly, signs and symptoms of limited scleroderma usually develop gradually. They include:
Tight, hardened skin. In limited scleroderma, skin changes typically affect only the lower arms and legs, including fingers and toes, and sometimes the face and throat. Skin can look shiny from being pulled taut over underlying bone. It may become difficult to bend your fingers or to open your mouth.
I have localized scleroderma (morphea) and want to have rhinoplasty and a chin implant performed. Are there any risks associated with having localized scleroderma and having these procedures done? Where can I got to find out information on this?
I just found out I have swallowing issues today via an esophageal manometry test, and the doctor said this could be tied to thyroid issues.... BUT my thyroid seems to be under control already with synthroid. Just curious to hear your thoughts.
Is there a relationship between cancer and scleroderma? I am involved with a small scleroderma group and we have had about 11 deaths to cancer with scleroderma. My sister also had scleroderma and ended up with lung cancer. The doctor is talking about treatment if i get any closer to cancer.
I am not sure I am posting this in the correct place. I am not so good with the comp.
i get my heart checked every 2 weeks now and i am fine with the qt thing. i take the chemo pill called gleevec and have to force myself to eat so i dont get sick when i take it. how long will these withdrawel problems go on? i have xanax to take (1mg) but dont work to good. i should would appreciate any advice from any one on how to deal with these issues, family dr says its anxiety but i think its the withdrawels from the high dose of elavil.
org/diseases-conditions/scleroderma/symptoms-causes/syc-20351952 Scleroderma is group of rare diseases that involve the hardening and tightening of the skin and connective tissues and can involve the esophagus.
I would recommend calling your doctor about the difficulty swallowing. Let us know how you are doing.
So within this year I have been having some things go on that are frustrating me. First it was tingling and soreness in my left arm. Went to my dr and he referred me to a chiropractor who says my neck is misaligned. I start getting adjustments until I couldn't afford it anymore, maybe 3 months. Then in June I start getting dry and blurry eyes off an on, which I assume is due to new glasses but it lasted way too long for that to be the issue.
I'm 18 and for a couple of years now my hands and feet, no matter what, are ice cold and normally pale blue in color. When I go outside my hands tense up, turn blue, and it hurts to move them and when they get warm again they turn a bright red. I researched this and found that is maybe something calls "Raynaud's phenomenom" which is a sort of syptom for scleroderma. My mother had scleroderma. Is raymaud's phenomenom what this problem is?
My right foot is always swollen on the top of my foot and 3 middle toes only. I have had this on and off for years and my GP doctor gave my a water pill to take. He thought I may have poor circulation in my leg. In the past, it would take care of the problem and the morning after rest, my foot would be fine until the next night. Exercise seems to aggravate the swelling. The past 2 months,nothing make a difference. It is not at all painful or uncomfortable.
Yes, nucleolar pattern is seen in scleroderma and in CREST Syndrome which is a type of systemic scleroderma. The other possibility is systemic sclerosis, again quite related to scleroderma. The ESR will be high and RA factor may be positive.
Do discuss this with your doctor. Take care!
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