Hi there.
It is important to be empathic, and let your brother know that you are always there for him. However, you should not overdo this, since this might lower your brother's self esteem further and cause him to have self-pity. CML is a manageable disease given the appropriate medications. Not all CML's are candidate for Gleevec. Only those who tested positive for the philadelphia chromosome or the bcr-abl gene would be candidates to receive gleevec.
Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
Hi.
Response to imatinib (gleevec) can be dramatic just like what you experienced. Myelosuppression with neutropenia (decrease in neutrophils) and thrombocytopenia (decrease in platelet count) can be a side effect of treatment. Usually, discontinuation of drug intake is advised until the blood counts increase. You should have your white blood cell count repeated after 1-2 weeks and see if it already improves. You should report to your doctor if you experience any symptoms like fever.
Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
I have raynaud and dealt with ulcerations for most of 30 years. I have low thyroid now also and have had reflux for some time now and on meds. I now have barretts and the next egd showed dysplasia stage 1. Is there a relationship between cancer and scleroderma? I am involved with a small scleroderma group and we have had about 11 deaths to cancer with scleroderma. My sister also had scleroderma and ended up with lung cancer. The doctor is talking about treatment if i get any closer to cancer.
i was diagnosed with cml in march of 2009 and was also taking 150mg of elavil at bedtime to control migraines for like 10 years. then this past dec. a heart test showed i had prolonged qt of the heart so i was stopped 'cold turkey' by a dr and its been down hill ever since. i have had the shakes, loss of appetite and constant nausea. i wake up evey morning shaky really bad.
//www.mayoclinic.org/diseases-conditions/scleroderma/symptoms-causes/syc-20351952 Scleroderma is group of rare diseases that involve the hardening and tightening of the skin and connective tissues and can involve the esophagus.
I would recommend calling your doctor about the difficulty swallowing. Let us know how you are doing.
I'm 18 and for a couple of years now my hands and feet, no matter what, are ice cold and normally pale blue in color. When I go outside my hands tense up, turn blue, and it hurts to move them and when they get warm again they turn a bright red. I researched this and found that is maybe something calls "Raynaud's phenomenom" which is a sort of syptom for scleroderma. My mother had scleroderma. Is raymaud's phenomenom what this problem is?
Are there any tests I should request?Also, I am wondering if I have Systematic Scleroderma. I do not have any skin issues at all. My hands are always cold;they do not change color or get painful. My right foot is always swollen on the top of my foot and 3 middle toes only. I have had this on and off for years and my GP doctor gave my a water pill to take. He thought I may have poor circulation in my leg.
Yes, nucleolar pattern is seen in scleroderma and in CREST Syndrome which is a type of systemic scleroderma. The other possibility is systemic sclerosis, again quite related to scleroderma. The ESR will be high and RA factor may be positive.
Do discuss this with your doctor. Take care!
My father had Scleroderma, he felt like it started because he was exposed to agent orange in Vietnam. Is there a good chance I will get it too?
I believe it was the SCL antibodies that I tested through the roof for scleroderma. The thing with the labs is you can test positive for things you don't have and negative for things you do. I know exactly how scary it is waiting for further test results and how one condition seems more terrifying than the next. Please keep in mind that when you read online about these conditions, you are reading about the full spectrum of the condition.
The nucleolar pattern is seen in scleroderma and in CREST Syndrome which is a type of systemic scleroderma. The other possibility is systemic sclerosis, again quite related to scleroderma. The ESR will be high and RA factor may be positive. Hence these two tests should be done. Please discuss with your doctor. Take care!
The medical advice given should not be considered a substitute for medical care provided by a doctor who can examine you.
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