00779/full
The last thing anybody would want is to stop the Gleevec, which is a wonder drug of anti-cancer treatment. So we must think of "managing" the hyponatremia problem.
I haven't found anything about long term use of Gleevec. But what springs to mind is that she might have started some other drug recently, which is turning mild hyponatremia to severe hyponatremia. Even ibuprofen. Has she?
I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
After two weeks on 400mlg gleevec my WBC droped from 36.5 to 7.1. My doctor told to come for additional test in two weeks. Now my WBC is 1.3 and absolute neutrophils count is 0.04. I was told to stay home on antibiotics. How long it may take for my counts to clime back to safe range. And of course, I'm off gleevec right now. Does it seem that dose of 400mlg is too high for me.
Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
Is it possible that after taking gleevec for only two weeks WBC droped from 36.7 to 7? All other blood counts are also came back to normal range. Could doctor make mistake in diagnosis of CML? Maybe I should get seg second opinion?
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
i get my heart checked every 2 weeks now and i am fine with the qt thing. i take the chemo pill called gleevec and have to force myself to eat so i dont get sick when i take it. how long will these withdrawel problems go on? i have xanax to take (1mg) but dont work to good. i should would appreciate any advice from any one on how to deal with these issues, family dr says its anxiety but i think its the withdrawels from the high dose of elavil.
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
Now her wbc is 58 and her hometown doctor is putting her back on Hydrea. Her family is concerned she is going to take a serious chemo drug when there is still a question of what she has. Could it be an infection that isn't showing up? Should she be put on antibiotics to see if that cures any underlying infection? Should they do more tests of any kind that you can suggest? She is JAK2 negative and PH negative also thus the atypical diagnosis.
You might find he starts to be able to tolerate the pill. Gleevec is first choice for treating CML, and if he is doing good in every other way then encourage him that he is doing great.
I hope this helps you. I would be glad to help you with any other questions.
Meanwhile, in mice that were prone to develop neurofibromas, the cancer drug Gleevec — an inhibitor of c-kit — reduced the metabolic activity and size of the tumors.
Because Gleevec is already prescribed for chronic myelogenous leukemia and other cancers, the researchers were able to secure fast regulatory approval for a phase 2 clinical trial of the drug in children and adults with neurofibromatosis type 1.
* buprenorphine Metabolized into norbuprenorphine by cytochrome-P450 isoenzyme 3A4
* Tyrosine kinase inhibitors, including Gleevec and Tasigna, used to treat chronic myelogenous leukemia and gastrointestinal tumors.
//www.cancer.org/Cancer/Leukemia-ChronicMyelomonocyticCMML/DetailedGuide/leukemia-chronic-myelomonocytic-survival-rates (from 07/25/2011)
"About 20 percent of CMML-1 patients and about 10 percent of CMML-2 patients survived longer than 5 years."
Also, what's your LDH? Any other markers tested?
Does your 28% apply to blood blasts? You haven't mentioned any BMBs being done - yet I'd think that would be automatic, so maybe your figures are for marrow and not blood.
He said that it was absurd to think that a five year study could demonstrate such a link, that it takes longer for a drug to cause cancer. I have to assume that he also thinks its absurd to think that it would only take five years for a drug to cause a cancer that was 'dormant' to become active (detectable). Do you agree?
For example, instead of having to wait to learn if a drug actually can extend the survival of cancer patients, the FDA might now approve a drug based on evidence that the drug shrinks tumors because tumor shrinkage is considered reasonably likely to predict a real clinical benefit. In this example, an approval based upon tumor shrinkage can occur far sooner than waiting to learn whether patients actually lived longer.
Edema (fluid accumulation in any body part, resulting in swelling) has been reported as an adverse event in 37% of pancreatic cancer patients taking Tarceva, although this side effect has not been reported in lung cancer cases.
However, the type of edema associated with Tarceva use is either generalized or involves a swelling of both legs. Swelling in only one leg may not be due to this drug. Unilateral leg swelling may be due to a local infection (cellulitis) in that area.
I have had a return of my ovarian cancer, from six years ago, now located in my lymph nodes. My oncologist originally put me on a protocol of paciltaxil, carboplatin, and gemcitibine for six months after my ovarian cancer surgery. Now she has started me on paciltaxil and carboplatin. However, I had a reaction after my second treatment, ninth overall after seven the first time, to the carboplatin with a spike in my blood pressure and a rash breakout.
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