filgrastim neupogen dose

The maximum tolerated dose of NEUPOGEN® has not been determined. Efficacy was demonstrated at doses of 4 to 8 mcg/kg/day in the phase 3 study of nonmyeloablative chemotherapy. Patients in the BMT studies received up to 138 mcg/kg/day without toxic effects‚ although there was a flattening of the dose response curve above daily doses of greater than 10 mcg/kg/day.

Do any of you have information about any long term side effects if you had Neupogen for 40 weeks?

t know if this is true of not, but maybe it will lessen or maybe the dose is too high. Your doctor is not helping by denying the pain is from Neupogen. If he/she won't admit it is from Neupogen then he/she is not going to be able to make a correct assessment and determine the appropriate treatment/relief. Have you considered a pain management clinic. I know this is different from chronic pain, but still they may have some ideas for relief.

Right now, the low neutrophils can be remedied with filgrastim (Neupogen, Neulasta), but nothing is prescribed for low platelets (whites involved in clotting) except for reducing the interferon. There is a drug (eltrombopag) that stimulates platelet formation but the FDA has not approved it to go with the HCV treament drugs, so insurance may not cover it. It is always better to use the rescue drugs instead of reducing the peginterferon or riba, especially if you have not cleared yet.

HI ALL,HOPING U CAN HELP ME OUT WITH WHERE TO FIND/BUY MEDS LIKE NEUPOGEN FOR LOW WBC,IV HAD LOTS OF TROUBLE WITH LOW WBC AND MY DOC SAID AUSTRALIA HAS NOT APPROVED IT. IM AN AUSSIE AND HOPING SOME1 KNOWS OF WHERE TO GET THIS STUFF,OR ANYTHING THAT WILL HELP.IV HAD MY DOSE LOWERED AND IT SHATTERS ME COS MY CHANCES WOULD BE MUCH HIGHER WITH FULL DOSE OF INTERFERON. I DONT CARE WHAT IT COSTS I JUST WANT TO BRING MY WBC UP COS IV HAD SO MANY INFECTIONS AND FLUES ETC.

Are you saying your mother in law has Leukemia? Filgastin or Neupogen is used for that. I don't know of other uses for it. She can't get it in the Philippines? If you can get a prescription from her doctor perhaps you can get it from a pharmacy here. Have a talk with a pharmacist here at one of the stores like Rite Aid, CVS any of those and see if they allow that.

Several people here have used it. Actually, what gets whacked is a component of the WBC call neutrophils - sometime referred absolute neutrophils or ANCs. These are a separate line item on a CBC report. Docs invoke the use of Neupogen at at different levels. I found the use of Neup to be a non-event, no side effects. Others expereince bone pain and injection site soreness. It's much better to use Neupogen than to reduce the dose of the Peg.

I believe neupogen lasts about a week. Neulasta is the same drug as neupogen (filgrastim) but is pegylated to keep it working on the bone marrow longer. Insurance paid for mine with a $100 co-pay. I cleared early and kept getting my peginterferon reduced for low platelets. I was freaked out at first to be dose-reduced. I remained clear regardless of the reduction and the study team did not seem to think it was a big deal. They were pretty worked up over keeping the riba up to full dose.

You can discuss ‘Neupogen (filgrastim) with the doc; this is a GCSF drug that stimulates bone marrow production of white cells. It is generally initiated when absolute neutrofils reach .500 or that vicinity; some docs allow closer to .350, depending on occupation and other matters.

Neulasta® (pegfilgrastim) or NEUPOGEN® (Filgrastim) may reduce your chance of getting an infection, but it does not prevent all infections. An infection can happen anytime your neutrophil counts are low. Look for signs of infection, such as fever, chills, rash, sore throat, diarrhea, or redness, swelling, or pain around a cut or sore. If you have any of these signs, contact your health care professional immediately. http://www.neulasta.com/starting-chemo-with-neulasta/about-neulasta-neupogen.

Yes, Neulasta is the pegylated version of Neupogen. A polyethylene glycol molecule or (“PEG”) is added to enlarge the Filgrastim molecule (Neupogen), thereby extending its half-life and causing it to be removed more slowly from the body. I don't know what the dosage requirements are for Neulasta but it is not taken as often as Neupogen.

NEUPOGEN® ( Filgrastim ) Program is designed to assist those patients who are medically indigent (patients may be uninsured or underinsured). Eligibility is based on patient's insurance status and income level.

Neulasta is a peglated version of Neupogen which is also know as filgrastim. It's used to stimulate production of neutrophils, a component of whilte blood cells. It can be taken less often than regular 'ol Neupogen. I found it rougher than Neupgen in that it had some side effects, mainly bone pain. I found Neupogen to be side-less. Aranesp is Darbepoetin Alfa which is like Procrit (epo). It is also taken less often than Procrit.

Neulasta is the expensive pegylated counterpart of neupogen. Same drug (filgrastim). Otherwise all you can do is reduce the interferon and it's generally considered better not to do that before you've cleared the virus. I don't know of any ways to reduce your risk of infection. What are you thinking of when you say that, please?

m small and the full dose of neupogen was too strong for me. My hepatologist agreed to allow me to take a half dose, which worked as well for me with less side effects. BTW: I did land up lowering my interferon dosage at week 12 and stopped taking neupogen altogether.

to compare the efficacy of two strategies of management of neutropenia--with Interferon dose modification and with Neupogen administration; to compare the effectiveness rate of sustained viral response (SVR) in patients with Pegylated Interferon dose modification and in patients treated by using granulocyte colony-stimulating factor G-CSF-filgrastim. (Neupogen). Study enrolled 47 patients with chronic active hepatitis C, aged 23-64. (38 male and 9 female). All patients had HCV genotype 1b.

Even then, the more aware docs will prescribe Neupogen rather than to reduce dose of interferon. Generally, interferon works on the the White Cells and neutrophils where riba abuses the Red Cells and hemoglobin.

I take 1/2 dose of Neupogen on Mon, Wed. and Sat. I inject the Pegasus on Friday. I was given the option of taking the Neupogen on Friday, to avoid 4 days of injections. I decided I rather do 4 days than 2 in one day. Pegasus and Neupogen can be taken on the same day. My doctor has assured me I can just about take it anytime without concern for tx. I trust his opinion in that he treats medical professionals from around the country.

Using the helper drug Neupogen is preferable to dose reduction. That said with ANC 650 neither may be required. My ANC dropped to 320 and I was allowed to continue full dose without Neupogen. A few weeks later ANC was over 1000 all by itself, ie ANC has a tendency to bounce around a lot.

A low WBC/ANC is usually the result of interferon and can be treated using drugs such as Filgrastim (Neupogen). Mine has been low since week 8, so on Neupogen 2x per week. For cancer treatment, a low ANC has a high risk of infection. However, there have been several publications to document that with HCV patients under trt, don't experience the same risk of infection. While some doctors get excited at levels between 0.75 and 1.

Briefly, Neupogen (generically filgrastim) is prescribed to increase low white blood cells as a result of interferon therapy. It’s also called a granulocyte colony stimulating factor, or GCSF drug. The labs used to track the need for this is the patient’s ‘absolute neutrofil’ count, located in the Complete Blood Count. Procrit (generically epoetin alpha) is used to stimulate bone marrow for production of red blood cells.

http://www.answers.com/topic/filgrastim-neupogen?cat=health The most common side effect from filgrastim is bone pain. The filgrastim causes the bone marrow to produce more white blood cells, and, as a result, patients may experience pain in their bones. http://www.rxlist.com/cgi/generic/filgrastim_ad.htm "In clinical trials involving over 350 patients receiving NEUPOGEN® ....

One, epoetin alfa (called Procrit or Epogen) stimulates the bone marrow to produce extra hemoglobin. The other, filgrastim (called Neulasta or Neupogen) stimulates bone marrow production of neutrophils, an important white blood cell destroyed by interferon. Most patients tolerate them well. It's good to have decent insurance, since it is always better to use the rescue drugs instead of reducing the dose of either interferon or ribivirin.

Filgrastim neupogen dose

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