Fenofibrate in combination with a Statin drug can cause severe Rhabdomyolysis. I know because I have gone through it. My muscle pain got so severe that I couldn't even move my arms and I wound up in the ER with kidney (also a muscle) pain so severe, I was climbing the walls.
The combined use of fibric acid derivatives and HMG-CoA reductase inhibitors has been associated, in the absence of a marked pharmacokinetic interaction, in numerous case reports, with rhabdomyolysis, markedly elevated creatine kinase (CK) levels and myoglobinuria, leading in a high proportion of cases to acute renal failure.
http://www.rxlist.com/tricor-drug.htm
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Some people have dangeroulsy high triglycerides and cholesterol.
I have noticed since I began taking fenofibrate that I experience cloudy urine after I eat certain foods. It only happens the first time I uninate after eating these foods and becomes clear thereafter. It seems that it is triggered with creamy and greasy foods. Is there cause for concern?
Thank you.
What will happen if an athlete with Rhabdomyolysis continues to play his sport? What will happen in the long run?
Ever since I started taking Zetia and Fenofibrate together as recommended by my DR, I have put on pounds, am more bloated around the belly,a nd have persistent chest pains. I noticed this has occurred ever since I have been on cholesterol lowering meds, but is more noticeable in the past year with the new combination of drugs. I mentioned this to my DR and he said I need the drugs because of my High Cholesterol. What do you think?
Since you know your CK levels, I assume you've seen a doctor about this? Do you have other symptoms, like muscle tenderness, nausea, etc?
In any case, high CK and dark urine are among the signs of rhabdomyolysis (google it), which is not a Good Thing. It's a breakdown of skeletal muscle. It can be caused by too- vigorous exercise, especially when dehydrated, among other things.
my mother,55y, she got her lab result with rising in cholesterol and triglyceride about 3month ago. she started to take fenofibrate 200mg once a day. and now new lab result show normal range of all types of fat. does she need to continue with a maintenance dose of fenofibrate or it isnt necessary?
This intense pain is a symptom of rhabdomyolysis,a rare condition that causes muscle cells to break down. This does not make your muscle tissue "mushy", it just causes cells t breakdown.
The most common signs and symptoms of rhabdomyolysis include:
* Severe muscle aching throughout the entire body
* Muscle weakness
* Dark or cola-colored urine
These symptoms usually occur in the first 90 days of treatment and happen in less than 1% of those taking Lipitor.
doctor has adviced me to take rosuvastatin and fenofibrate tablets.can you please tell me whether it helps to reduce weight?
Your numbers are high, but you need to look at the breakdown. First off, your TGL's should be under 150. Not hard, just cut out the empty carbs like breads, sugars, pastas etc. Also, drinking will elevate your TGL's so don't over do it. You could start on a Fenofibrate like Tricor to lower your TGL's it works well. A statin will not really do that much.
Vytorin does a remarkable job of reducing your Cholesterol, much better than Zocor (Simvastatin) alone. However, Zetia doesn't seem to add anything to the picture as far as preventing heart disease is concened. But read this about Zocor:
-"Zocor Users Not Warned of Risks:
The FDA's June 2011 safety alert is the most serious of many warnings regarding Zocor and associated risks of myopathy and rhabdomyolysis. Zocor manufacturer Merck & Co.
Rhabdomyolysis is a life-threatening condition that results from myositis, a condition which destroys muscle cells causing pain, particularly in the calves and lower back. The condition can become so severe that it leads to kidney failure. Symptoms of rhabdomyolysis include, but may not be limited to, muscle pain, weakness, tenderness, fever, dark urine, nausea, and vomiting.
MB bands which are Cardiac Bands and MM bands which are muscle bands. Weight lifters or people with rhabdomyolysis can knock the MM bands way out of whack. Muscle breakdown will throw the MM band quite high.
You can google the warnings and side effects of that one. I also take Tricor for my hyperlipidemia. But that is a fenofibrate, not a statin. Have you ever tried the grandfather of statins, Lipitor? Talk to your doctor and get the straight answers.
About 4 years ago, I was overworked by a personal trainer in the gym and ended up in the hospital for 5 days due to Rhabdomyolysis. I had never heard of this disease before this day. Turns out the trainer overworked me. Needless to say, I am not a big fan of exercise since then. I've dabbled with it over the past few years.
Exercise will help increase your HDL which should be over 40. Make sure to ask your doctor before starting any exercise. You can also as about a fenofibrate, they are very effective at lowering your TGLs.
Did your doctor prescribe 2,000 per day and is that what you took? Your post is also not clear when you say consecutive 3-4 dosing at 2,000.
Meds I am currently on are levothyroxine and fenofibrate. I was on buspirone but just quit that a few days ago. I did have this happen one other time a few weeks ago, but the second time after that everything was normal, so I wasn't worried. I believe at that time I was off the meds or just starting them.
s are easy to lower, cut back on all sugars, breads, pastas and alcohol, that usually is enough. If not, you can try a Fenofibrate which is a very effective drug.
Rhabdomyolysis, kidney problems so that I ultimately had to stop them, but knee burning/pain while walking wasn't one of them.
Hi I was recently prescribed Fenofibrate to help reduce my high cholesterol levels etc... after a blood test.
I have been doing some digging around regarding the drug and it says I should not be taking it if one has Hep B.
I haven't found what the reasons are so I was wondering if someone could elaborate why one should not be taking it if one has Hep B.
Thanks so much for your help.
Please help me .My Serum Ige level is on the increase from 1150 to 1370 in just 3 weeks.
I have hypothyroidism,I have high triglycerides 479 & cholesterol level 270.I have been prescribed Fenofibrate 200 mg for triglycerides & Zatofen 1 mg for serum Ige,but these medicines causing too many side effects back pain,knee pain.restless legs & insomnia.Please help.
Those tests showed that my CPK levels exceeded 135,000 and i was diagnosed with Rhabdomyolysis. All other tests did not reveal the cause of the Rhabdomyolysis but no-one at the hospital seemed to have ever heard of cpk levels this high. My searches on the internet have also not revealed any levels nearing this. I am now down to 4000 (and hopefully dropping).
any thoughts?
have there been other cases with cpk levels exceeding 135,000 and what was the cause?
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