Etanercept demyelination
Common Questions and Answers about Etanercept demyelination
enbrel
Etanercept Study Group.
Division of Gastroenterology and Hepatology and Internal Medicine, Mayo Clinic, Rochester, MN, USA. ***@****
BACKGROUND/AIMS: Current therapies for patients with chronic hepatitis C virus (HCV) do not achieve sustained viral clearance in most patients, and are associated with severe toxic effects. Our aim was to investigate the efficacy and safety of etanercept as adjuvant to interferon and ribavirin in treatment-naive patients with HCV.
Can a perispinal etanercept injection help heal severe pain linked to the piriformous muscle?
Can anyone tell me if peri spinal etanercept works ? I have had four back surgeries since 2000. The last two were for decompression of the L-4, L-5 and S-1 nerve roots. My third surgery was performed in January 2011 and the last one in July 2012. I am still having pain around my right hip, left calf , left ankle and left foot. MRI and CT Myloegram do not show anything. Help !
The standard therapy options include intravenous immunoglobulin and plasmapharesis, corticosteroids, azathioprine, cyclophosphamide, etanercept, mycophenolate mofetil, interferon alpha 2a and tacrolimus. Current ones are interferon beta 1a, rituximab, and high dose cyclophosphamide. Your neurologist needs to apprise you of the long-term side effects since prolonged therapy are required. Botox shots are not known to be used in therapy.
MRI Brain=Areas of multifocal subcortical and deep white matter signal abnormalities, hyperintense lesions. In a patient of this age, this could relate to demyelination. Chronic ischemic is less likely.
Both MRI's were done without contrast.
Finally got my referral to a neurologist. My age is 45 and still trying to piece this out is confusing.
Any advice, still new at this. Yes, I am aware this could be from headaches, migraines, etc.
Differential considerations are within normal ranges, miscrovascular ishemic demyelination and demyelination disease.
These symptoms didn't start all at once. It started off, in 2005, with a simple pins & needles sensation in my left foot and from this, the symptoms progressed. As of the beginning of this year 2011, I have now completely lost the sensation in both my feet (toes and heels) and both feet go numb during the course of the day and night.
Quix posted this yesterday:
------
I have been reading, these last two years, of neurologists that make the diagnosis of
"Demyelinating Disease" and stop. They go no further in the diagnosis. Yes, there are some other diseases that cause demyelination in the CNS, like ADEM, infections, Devic's. BUT, FAR AND AWAY THE MOST COMMON IS MS. It is the neurologist's duty to put a name to the "demyelinating disease.
Does psilocybin (an active component in magic mushrooms) cause multifocal demyelination, which leads to multiple sclerosis? A few my friends do mushrooms couple times a year, and I myself done them 2 or 3 times, neither I or them have symptoms, but I'm worried. Found only few clues about connection between psilocybin and demyelination on the Internet.
Thank you.
Apart from clinical neurological examination, MRI shows MS as paler areas of demyelination, two different episodes of demyelination separated by one month in at least two different brain locations. Spinal tap is done and CSF electrophoresis reveals oligoclonal bands suggestive of immune activity, which is suggestive but not diagnostic of MS. Demyelinating neurons, transmit nerve signals slower than non-demyelinated ones and can be detected with EP tests.
Myelopathy is caused by either trauma or inflammation of the spinal cord. MS is a demyelination (an erosion of the covering) of nerves in the brain or spinal cord caused by the body immune system.
Neuronal loss is found in various diseases such as neurodegnerative disorders. Examples are Alzheimers, MS, Parkinsons, ALS, Huntingtons disease etc. Demyelination is stripping of the covering (sheath) of a nerve. This also found in the diseases above.
Although there is increased signal on the diffusion weighted sequence there is no correspondingly low signal on ADC Map which suggest T2 shine through. Non specific demyelination is favored. Sulcation pattern is also prominent. The major intracranial flow voids are intact.
Hi Cindy - Welcome to our world :-)
The description you provided sounds like it was taken from radiologist's report. These reports are, more often than not, written in a language that mere mortals cannot decipher :-)
All that can be determined form the information here is that the radiologist saw something on the image and that demyelination can't be ruled out as a cause. Demyelination is the damage to the myelin coating that surrounds nerves in the central nervous system.
5) punctate FLAIR hyperintensities in the periventricular white matter of both frontal lobes are nonspecific and could be is sequela of chronic microvascular ischemia or demyelination. Rest of the brain is normal in signal intensity. The ventricles, basal cisterns and sulci are normal.
There is no abnormal enhancement in the brain or meninges. There is no edema, mass effect, or midline shift. There is no intracranial hemorrhage or evidence to indicate acute infarction.
The sella is normal.
Recommended
