Statistical analysis showed that during the 25 years of follow-up, women who had removal of normal ovaries had a higher all-cause mortality rate, mainly from coronary heart disease and lung cancer. Although there was a lower incidence of breast cancer, ovarian cancer, and in fact all cancers in the women who had their ovaries removed, the risk of death from cancer was higher.
At no stage of the study was survival higher for the women whose ovaries were removed.
Hi. Which particular "chemosensitivity test" are you referring to? There is no single laboratory procedure which can test for the sensitivity to chemotherapy of all types of tumors. In breast cancer, there's the Estrogen Receptor (ER) and Progesterone Receptor (PR) assays to determine sensitivity to hormonal treatment. There's also the HER-2 (human epidermal growth factor receptor 2) assay for determining sensitivity to Trastuzumab.
My pathology report showed that my ovarian cancer was estrogen receptive/reactive. So why is HRT okay? My local gyno-oncologist and my gyno-oncologist at the Fred Hutchinson Center in Seattle both indicated it was okay. I like being on estrogen, but I am concerned because it seems risky. What is your opinion?
My ovarie(s) are being removed due to my need to be estorgen free due to a Breast cancer tumor that was estrogen possitive and then me getting a blood clot in each lung due to Tamoxifin. Surgery is February and lapriscopic, outpatient. What I am most concerned about is how to deal with the onset of an instant menopausal stae as op[posed to a gradual inro to menopause.
When present, this gene variant increases the risk of lung cancer, especially the risk for small cell lung cancer. Your mother may or may not have this gene variant but that doesn’t mean that you have it. And, if you do have it, the increased risk, in no way, means that you will get lung cancer, small cell or other, especially now that you have quit smoking.
The role of lung cancer screening tests is still not clear.
When my mother was diagnosed with ovarian cancer 9 years ago, she went through a full hysterectomy and additional chemotherapy treatments for a full year following surgery. The cancer had gone into remission and had been there for 7 years. In 2008, she had been re-diagnosed with the same cancer. Only this time it spanned the wall of her bladder, attached itself to the pelvic cavity and metastasized to the lower lung. She received additional chemotherapy treatment to combat this.
2-1/2 years ago I had breast cancer and was prescribed Anastrazole which blocks the estrogen from my body as the tumor was estrogen feeding. All of a sudden and very quickly I have now developed crepey skin on my arms and cleavage. Has anyone else noticed this from taking an estrogen-blocking agent? I am so tempted to stop taking this pill, but I have 2-1/2 more years to go and don't want cancer to recur. I am 69 but I will look like 95 by the time this is over.
Congratulations on your eight years! I hate to be the one to say this but there is no such thing as "out of the woods" with cancer, I wish there was.
What you've done is reduced your risk for another estrogen positive breast cancer and ovarian cancer. But that doesn't mean you won't get a different type of breast cancer in the remaining breast tissue or another part of your body.
But you know as well as I do that each year we are NED with cancer is better for our odds.
Estring, for example, releases over 90 days an amount equivalent to taking oral estrogen for just 2 days, and Vagifem, aready a very low dose estrogen product, is now available in a 10 mcg dose, as well as the original 20 mcg dose. (Both of these are reported to be preferrable to a similar third product, Estrace.) These products also appear to have a very, very low level of systemic absorption.
Just to add to what Lauren said regarding tamoxifen vs. other AI's, they do work differently in the body. Tamoxifen works by blocking the body's use of estrogen, whereas AI's reduce the amount of estrogen present in the body. In studies of breast cancer patients, AI's have proven to work better than tamoxifen in preventing recurrence, and there are far fewer serious side effects with AI's than with tamoxifen, too. Tamoxifen can cause blood clots, and stroke..
However, in this case, there is no mass in the lung at all, only something in the bone. It would be pretty unlikely for cancer in the lung to present in this manner.
The question would be if the finding in the bone appears malignant. If this was the case, it would likely have been discussed with you. An abnormal bone island or cyst is not cancer, but due to its presence, it may produce pain.
Discuss the nature of the shoulder finding with the doctor and make a plan as to what's next.
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