Please note Tenofovir is principally cleared through the kidney and dosing adjustments due to renal impairment have not been clinically tested.
The followings are extracts from the label information for Tenofovir:
2.3 Dose Adjustment for Renal Impairment in Adults
Significantly increased drug exposures occurred when VIREAD was administered to subjects with moderate to severe renal impairment [See Clinical Pharmacology (12.3)].
I am not aware that impaired renal function precludes treatment for HCV. I have read that kidney disease is a negative predictor of SVR but, so too are a lot of conditions yet people have overcome them. I have seen articles which discuss the plasma levels of ribavirin with renal impaired patients. The suggestion is that rather than weight base dose these patients the dose should be arrived at by considering GFR (glomerular filtration rate).
This is from Clinical Care Options @ http://tiny.
It is 72 hours post-exposure for me right now and I took the triple therapy that I have-- Epivir, Viread, and AZT. I took a dose of Epivir and Viread at 42 hours and then decided I was being paranoid he didn't use a condom [since I only have his word] but read your post and got nervous, so I took a dose of Epivir and Viread late by 6 hours. I started the AZT for the first time at about 72 hours.
Epivir=Lamivudine, said to be very safe for husband and wife who wish to have children. But do you have to choose Lamivudine as first-line treatment with its high resistance profile?
Hi everyone,
I went to see my Dr today and he recommanded to change my medicine to Viread (I am on Epivir more than 2 years). I am wondering if it's necessary to change it now since Epivir works well with me (my DNA is 200 copies). But he was worried about resistance and mutation. Do I have to listen to him? I got Viread today but I am not sure I would start taking it from today.
-Natalie
p.s.: Do you guys drink coffee? I started drinking coffee about 4 months ago...
By "AGE" I'm assuming you mean a persons age in years. I don't believe age has anything to do with Janumet's "effectiveness" but age has a larger role with renal function. To make it clear for other readers, Janumet is combination of two drugs; Sitagiptin and Metformin.
This a brief from the Merck web site - makers of Janumet - Section 8.5 - Geriatric Use JANUMET.
I also have kidney damage from a bout of high blood pressure 4 years ago, and I am a frequent kidney stone former, so I am being watched carefully by a nephrologist too. I have renal panels frequently too. I was wondering if any of this could increase my stone risk. I was reading about the cytomel and stones. The nephrologist wants me to remain on the synthroid and cytomel.
I was diagnosed Hep B 13 years ago, and have taken Epivir since 2002. I do blood test and ultra-sound every 6 months and Hep B is controlled pretty well. As you know, Epivir cause virus mutant resistance, and chance is higher for me since I have been on it for 5 years. My doctor gave me 2 choices,
1) "don't fix it until it breaks" - continue with Epivir, move to combo treatment when mutant and resistance evidence shows up.
2) "precautious way" - take baraclude.
I think it depends on some individual factors, particularly renal clearance of the drug. I found this information in the drug reference:
According to the manufacturer's tests, the drug reaches maximum serum levels between 15 and 44 hours after subcutaneous injection of a single dose. The mean elimination half-life is 22 to 60 hours (mean = 40 hours). So, I would expect that after 7 days (4.2 half-lifes) that the concentration would be about 5.5% (0.5^4.2) of the maximum levels.
Just wondering, I had a liver transplant three years ago. They said the donor had a HBV antibody but they did not detect HBV. I decided to go ahead and go through with the the transplant. The doctors said 1 to 2% chance of HBV appearing. I had been vaccinated (the three shots) about 15 years earlier and so I have HBV antibodies.
After the transplant my doctors said I should go ahead and take Epivir just in case they'd missed something.
1 Does this mean I do not respond to Tyzeka?
2. Should I change to Ziread since it is approved.
3. I have experienced elbow pain, left arm, with Tzyeka.
4. Does changing drugs instead of stopping altogether cause flare up?
Previouusely I took EPIVIR for 7 years and Hepsera for one year.
Thank you.
t remember, should I take the AZT with my Viread and Epivir for a more potent PEP regimen? Or is Viread and Epivir alone okay? I have no side effects from them.
Given that this is a gay sex club in NYC, an epicenter of the epidemic? Is it possible to forget having anal sex as a top? I am not a frequent visitor to sex clubs. I do have a phobia of "forgetting" anal sex when I'm drunk- though I've never forgotten it ever before.
I treated with hep b 14 years ago for 1.5 years with epivir and got hbv e antibodies and afterwards, I stop epivir and every 6 months I check my liver function and alt and ast are persistently normal. I started to check hbv dna 6 months ago as new guidelines come out. Hbv dna at six month was 5000 iu/ml and last week I checked it was 8000 iu/ml. Again both times my alt and ast are normal. As a matter of fact they are in low side of normal.
Glomerular filtration rate or its approximation of the creatinine clearance are measured whenever renal disease is suspected or careful dosing of nephrotoxic drugs is required. The normal ranges of GFR, adjusted for body surface area for males is 70 ± 14 mL/min/m2 (56-84) . Risk factors for kidney disease include diabetes, high blood pressure, family history and older age.
Take care and keep us posted.
I was wondering given the following conditions - 1) HBV is UND (<357/IU) 2) On Epivir for the last several years because after some surgery the doctors thought it was possible I had been exposed to HBV or got some tainted blood 3) previously had the HBV vaccine 15 years ago. 4) No signs of HBV.
I was given Epivir, Viread and Zidovudine.
There are preferred opiates drugs that are use in patients with liver disease that have shorter half-lives and have less harmful side effects on the renal system. Your liver doctor should be aware of these drugs and be able to determine if you may be able to use them.
With regards to OTC medications, normal recommended doses of acetaminophen can be safely given to patients who suffer from cirrhosis in the short term.
However, I was prescribed Combivir and Epivir (only-not a third drug) for 28 days and during this time I had a cold with a sore throat and headache for almost the whole period up to a few days ago. It is now almost 7 weeks since I had the sexual encounter in Bangkok. After 30 days I had an HIV test and the result was negative. I am now going to have a test at 8 weeks. I am worried to death and I wonder if the PEP I was prescribed has been wrong or not sufficient.
But regarding this Vit D , should i need to take along with calcium supllements Or no need? I have renal stones of 0.5mm. Does this have any effect on this?
If you are stage 3 you can take any analgesic within dosing limits. Your liver function has not been altered by your liver disease yet. If you become stage 4 (cirrhosis) then you will have to modify what drugs you can take because the liver is no longer able to process drugs in a normal manner.
Tramadol is an synthetic opiate and should not be taken for "mild" pain.
I have been taking EPIVIR HB 100mg because I have been diagnostic with Hepatitis B. Recently I had blood test for Hepatitis Be Antigen and Hepatitis Be Antibody. My results indicate the following Hepatitis Be Antigen nonreactive and Hepatitis Be Antibody reactive. What can I make of these results?
Call your local pharmacist. We at MedHelp are not allowed to give out dosing instructions. Your pharmacist will be able to tell you exactly how to dose the medications. If your regular pharmacy is closed on Sunday, call any pharmacist availabe at your local grocery store or drug store such as Walgreens, CVS, or RiteAid.
RENAL RISK
TORADOL is CONTRAINDICATED in patients with advanced renal impairment and in patients at risk for renal failure due to volume depletion (see WARNINGS).
RISK OF BLEEDING
TORADOL inhibits platelet function and is, therefore, CONTRAINDICATED in patients with suspected or confirmed cerebrovascular bleeding, patients with hemorrhagic diathesis, incomplete hemostasis and those at high risk of bleeding (see WARNINGS and PRECAUTIONS).
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