The most common side effects of Truvada are the same as with tenofovir (Viread) and
emtricitabine (Emtriva). They include headache, nausea, vomiting, rash and loss
of appetite. In some people, tenofovir can increase creatinine and transaminases. These are enzymes related to the kidneys and liver. High levels can indicate damage to these organs.
Tenofovir can reduce bone mineral density (see fact sheet 557). Calcium or vitamin D supplements may be helpful.