Currently DESCOVY 25mg TAF plus 200mg emtricitabine is alead approved for hiv in the USA and canada. It could well be used for hbv, most likely at 1/2 tablet a day for hbv for patients who do not tolerate viread.
the emtricitabine. ..also called FTC, is also used in TRUVADA at the same dose, which is frequently used by hepatologists for patients with a suboptimal response to viread.
Most participants in the study were Asian and the average age was 33. Nearly all were HBeAg-positive and had HBV DNA levels at around 10 million IU/mL. Sixty-four patients were treated with tenofovir (300 mg daily) and 62 were treated with the combination pill containing tenofovir (300 mg) and emtricitabine (200 mg).
Well here it is guys something that has been talked on the HIV forums for years they NUCS cause high blood pressure is finally have been labeled as side effect. Does not mean it will happen with everybody but it sure did happen to me taking Entecavir (Baraclude) which was also originally developed for HIV but it failed miserably as they virus developed resistance really fast to it..
hbvdna intrahepatic needs to be suppressed as much as possible and hbvdna in serum undetactable to rescue some immune response so that peginterferon response is 90% or higher
monotherapies are all a failure, they are not a hbv cure and they just stop liver damage by lowering hbv replication
How do you differentiate an infected patient from an immunised client serologically
hbsab>10miu/ml only, immune by vaccine
hbsab>10miu/ml with hbcab positive too, immune after hbv clearance
cronic i
the explanation of why tenofovir is so potent on hbv and makes no resistance was explained by the intracellular levels reached by this drug, it is so bad no study ever showed how all other nucs are extremely poor at this and when i found this comparison i was very very surprised
all ohter drugs are so weak as intracellular levels, just look at lam vs tdf.we dont have etv here but it is probably very poor too.
You are correct that Truvada is a combination of tenofovir and emtricitabine, and is generally prescribed for patients with HIV. Being a HBV forum, most of us know very little about Truvada except that it is prescribed off-label for HBV by some doctors, and that it is recommended for HBV patients who develop resistance to Tenofovir.
Due to the extremely low susceptibility to resistance and very low toxicity this drug became the cornerstone of antiviral treatment for HIV and HBV. It made Gilead Billions, of which Holy has seen a million a year grant for his Institute in Prague.
At the day he died, the FDA had approved Truvada, a combo of tenofovir and emtricitabine (FTC) (300/200mg) for use as a preventative in healthy individuals exposed to risk of infection.
Brief Intro: have been on Truvada for more than 3 years now, switching from LAM (lam resistance, I took lam for 3 years). HBeAg +, AntiHBe - , 25 years old, genotype B.
Ultrasound, fibroscan (around 5.0 kPa) & blood test (AST, ALT, Creatinin,... HBV DNA undetectable) every 6 months comes back normal (been doing this for 5 years now).
I'm thinking about taking Tenofovir only because I will move to a place where Emtricitabine is not available. I know it is better to combo.
t think, basing dosing on HIV folks is the right way to go for HBV treatment strategies. HBV and HIV do not even compare in terms of damage that HIV does to the whole body at once.
And they may as well have made an improvement to the drug. So I think it is a good thing if they keep the same potency at lower dose. Because it is very true that how much of it is absorbed by cells that is what really counts..
Conclusion
This case report suggests that Delta infection may co-exist with high replicative HBV infection and that combination therapy with PegIFN and nucleoside/tide analogues seems to be more effective than IFN alone. Given that only a single case is reported, further studies including more patients are warranted.
Immune-tolerant patients received tenofovir disoproxil fumarate and/or emtricitabine for 4 years and were followed for another 4 years after treatment cessation. Virological relapse was defined as hepatitis B virus (HBV) DNA>2000 IU/mL; clinical relapse was defined as HBV DNA>2000 IU/mL; and alanine aminotransferase (ALT)>2 times the upper limit of normal. Results: In total, 20 patients stopped treatment and were followed up for 206±14 weeks.
No Detectable Resistance to Tenofovir Disoproxil Fumarate (TDF) Following up to 240 Weeks of Treatment in Patients with HBeAg+ and HBeAg- Chronic Hepatitis B Virus Infection
P. Marcellin1; E. Heathcote2; A. Corsa3; Y. Liu3; M. D. Miller3; K. M. Kitrinos3
1. Hopital Beaujon, University of Paris, Clichy, France.
2. Toronto General Hospital, Toronto, ON, Canada.
3. Gilead Sciences, Inc., Foster City, CA, United States.
The most common treatment in the US, Canada and the UK is Truvada. This is what is known as a "fixed-dose combination tablet" combining emtricitabine and tenofovir from the NRTI class, and raltegravir, from the integrase inhibitor class. There ARE alternative drugs available and possibly in Thailand they use lamivudine in place of raltegravir. I am definitely NOT a chemist, so I can't tell you for sure if the combination you're taking is appropriate.
I was also a reciever. After 40 hours I went to the first clinic and they gave me PEP (TenofovirDF, emtricitabine + lamivudine). The clinic looks very unprofessional, but it was my only chance. I didn't do any hiv or std test, a month before the exposure i had HIV test which was negative. After few days I had a mild sore throat, i still have it, i don't have fever, running nose, rash or anything else. My questions are..
Five years ago they were right on the spot with Baraclude saying it is weak drug and resistance issue will be a problem with HBV.. They were suggesting me to take Tenofovir. but I didn't and went with the Baraclude that was recommended by UCSD Hepatologist that now tells me interferon is better :)
But Truvada is optimized to be less toxic. Because NUCS toxicity is a big theme with HIV folks and from what I have read on their forums people say Truvada is very tolerable.
What are my chances of getting infected. Another question was administered a PEP drug emtricitabine and tenofovir, can it prevent me from contracting HiV.
Perhaps HR can tell us wheher that's the info he was refering to. It comes from a site that teaches doctors how to treat Hep B.
Check out the topics in the advanced program, some of them pertain to you (like the one on genotypes).
The first article says patients with a persistently normal serum ALT, irrespective of HBeAg status, are also at risk for the development of cirrhosis and hepatocellular carcinoma, especially if their HBV DNA is > 4 logs.
My doctor told me that the virus mutated, and resisted to Lamivudine. My HBV DNA at that time was 24 million copies. I also did a liver biopsy, and that came up with a stage 2 (I think I was told there were some visible scar on my liver)
Started treatment with Truvada 2 years ago, got undetectable HBV DNA within 5 months. Also, my abdominal ultrasound came normal. AST, ALT, AFP, CBC in range.
My recent labs came up as follow:
These labs were done outside of the U.S.
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