dipyridamole and adenosine

While adverse effects are less frequent with dipyridamole (47% of patients), they tend to be more serious than those associated with adenosine. The most common adverse effects of dipyridamole are chest pain (19%), headache (12%), and hypotension (4.6%). In addition, 12% of patients require aminophylline for reversal of adverse effects.

False negative imaging is especially common when exercise is submaximal or in dipyridamole/adenosine studies of patients with severe obstructions of all three major coronary vessels. False positive scanning may be caused by signal attenuation from an elevated left hemidiaphragm or from breast tissue. These artifactual defects can be identified by performing a gated perfusion study to assess regional wall motion.

As you are saying, caffeine is a adenosine receptor blocker (it binds to the same parts of your cells as adenosine) and will make adenosine less effective (to some degree). It's possible this is why adenosine was ineffective. You should ask those questions to your doctor, though.

I can only answer from my own experience, but I have had adenosine several times as well as taken metoprolol and a couple of other beta blockers and never had any memory problems or brain fog. Adenosine is very short acting with a half life of only seconds, so I really doubt it would have long standing side effects, but I am not a doctor.

Persantine is dipyridamole, but you will have to get extended release tablets as the two asprin and dipyridamole should not be taken together. Don’t change the medications without discussing with your doctor. So, consult him and then decide. Hope this helped and do keep us posted.

What is nonreversible apical inferior wall and what does it mean when they say no dipyridamole-induced reversible ischemia .there is mild defect in the apical inferior wall that is not reversible at rest.

thanfully i had no brain damage but i was so confused,finally my cardiologist came in and told me what happened. for some reason my heart did not take well to the adenosine and i actually went into asystole for 30 whole seconds. he told me that they quickly gave me an atropine IV and i opened my eyes..i do not remember any of that. they took me to the ICU for observation and i just got back home. i am now so damn scared,i will never go to the hospital even in the worst cases of A-fib.

Some of the alternatives include aspirin, Clopidogrel (Plavix), ticlodipine (Ticlid), dipyridamole (Persantine). Another alternative is Heparin injection. Different situations require different levels of anticoagulation. It is important to discuss the best treatment option with a physician.

Every time I have had it I have gone to the ER and they gave me the adenosine. I do remember the dr telling me to put my thumb in my mouth and blow really hard but it didn't work. The 1st time I had it I had to have the adenosine twice, the 2nd time once....the sensation is so scary, I really pray I don't have to have it ever again.

You can say, caffeine works most effective towards about the same parts of the heart that are sensitive towards adenosine. In other words, the atria, the AV node and to a certain degree the RVOT (where I assume from another post that your PVCs did origin). Caffeine is an adenosine antagonist, which means the caffeine blocks those receptors (which is why people drinking a lot of coffee complains that their SVT is hard to convert with adenosine, there are a couple of those posts here).

Can you help me understand exactly what this is and how it works, and if it is dangerous and what side effects could she have.

If those measures fail to terminate the SVT than Adenosine, is safe and effective in terminating SVT. It is rapidly metabolized with a very short half-life, making it ideally suitable for use in pregnancy. If adenosine fails, other antiarrhythmics may be indicated and the risk of their use should be weighed against the risk of continuing SVT. Beta-blockers have been used extensively in pregnancy, to treat maternal hypertension and cardiac problems, and are generally well tolerated.

I am more afraid of the sensation of having the SVT than of the Adenosine to cure it. Yes the Adenosine feels awful but the relief I feel when my heart resets - emotionally - makes the Adenosine sensations worth it. I've had Adenosine 7-8 total in my life and the very first time I had it was probably the scariest. All other times I was actually asking for it by the time the medics arrived.

I suffered a mild stroke (blood clot) Consultant prescribed Clopidogrel but cannot tolerate side effects. Then consultant prescribed Dipyridamole. I cannot tolerate this either. Severe headache, vomiting and diarrhoea. Has anybody got a different medication they are on?

The cardiologist said to take it the night before the test since It was an adenosine test instead of treadmill testing. The conclusions of the Dr. were ejection fraction of 49% after administration of adenosine and no abnormal segmental wall motion abnormalities. There were no significant ST segment depressions, and no chest pain with adenosine. My question is the 49% ejection fraction compared to the 75% ejection fraction on the echo in Janurary.

My rx says adenosine nuclear stress test. Adenosine is used in lieu of exercise.

thallium mibi stress scan..... i was not able to pass the stress test ... they injected adenosine and i got fast heart rate and pani attack they had to stop the test.... then the doctor said we will use treadmill for stress ( it will be done after some days) i was ashamed that i couldn't pass the stress test i was embarrassed..............cardiologist has said that you need to see a psychologist asap...... i have sleepless nights always thinking about my brother......

I have never tried it, but assume will work like the Adenosine. So, I can take that each and every time it happens (which is getting more frequent). or I can probably have the ablation, with the risks that entails. What would you do? I have no heart disease/structural issues according to a echocardiogram.

Those should be fine, although WPW rarely causes cardiac arrest, if you going into afib or some other SVT those AEDs will not work. To my knowledge it is drugs which are dangerous in WPW like adenosine and you may want to wear a braclet saying you have WPW just in case.

Hello I have been reading these forums regarding living with PSVT and such. My PSVT episodes occur in groups every few years. I have a little cycle where I have a PSVT episode requireing the Adenosine IV, then I get anxious about having a PSVT episode requiring an Adnosine IV, which of course, causes me to be anxious enough that I am more likely to have one. My anxiety always seems to go up around the same time I have a cycle of a few PSVT episodes - and this cycle reoccurs every few years.

ECG last month showed SVES, RBBB. This week he has stress test with dipyridamole protocol, and injection of thallium-201. The result showed "evidence of mild, small to medium size, irreversible perfusion defect in the inferior/inferolateral wall (mid to basal level)." Could you explain what this means? Does he need to have surgery or pacemaker? thanks in advance for your help.

I just came across and article that says "Adenosine and other AV node blockers should be avoided in atrial fibrillation and atrial flutter with WPW or history of it; this includes adenosine, diltiazem, verapamil, other calcium channel blockers and beta-blockers." And my son is on atenolol for WPW. Should I be concerned?

I looked at the package and ASASANTIN is a brand name for DIPYRIDAMOLE/ASPIRIN. Thought I would clarify that.

My SVT before my ablation had me in the ER...with an adenosine push. The last one was in Dec 07 and they had to push adenosine twice before it brought my heart rate back down. The time before that, one injection and that was enough. The one in Dec. I was on beta blockers, so I thought one injection would do the trick but it didn't I was very nervous at the thought of them starting my SVT during the ablation, but I was not awake and didn't know a thing.

Is she still having the affect of adenosine and should she stop atenolol for a few days? is surgery neccessary for her to eliminate SVT? Is SVT dangerous? is the procedure fixing SVT relatively safe (e.g. low risk)? BTW, her parents and her 2 older brothers passed away in their 40s due to heart disease. Her 3rd brother had heart attack in his 40s and currently on medications. Could her heart problem be genertic?

welcome to the club!! don't worry about your heart going to 300. i think my record is about 285, and they just give you the adenosine. i can't give you any advice on the ablation because i've not had it done, but i'm planning on it this summer or next. one thing i do NOT recommend: whatever you do, no matter how strong the urge, DON'T GOOGLE IT!!! you will only freak yourself out. i've seen videos and it's really not that bad, just scary sounding. good luck!!

Dipyridamole and adenosine

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