Do you mean Metoprolol? This is the
generic Toprol medication all are slow release, SL as far as I know. But, you may be talking about something else.
I respond because I have been on both Toprol and Metoprolol for periods of time, the latest has been about a year now. My dose has been much higher, as high as 200 mg a day (2x100mg). While this has given me undesirable side effects I am not aware of one being depression. I've read the warnings, maybe I've overlooked.