- Absorption, oral: time to peak concentration 7h
- Elimination half-life = 12 h
(It says also that in general it can be administered once daily because it has a 24 h effect.Why?)
- Can you give another example to clarify it better please?
- When it says divide in 2 doses , does it mean only in the morning and dinner? 3 doses (morning-lunch-dinner)?
Thank you for taking the time to answer!!
i started use Desogestrel in december at start when my period came was all fine period was gone after 4 days. january 4th started some lil bleeding and spotting and didnt stopped ever since. like 3 weeks ago i went to my doctor she said lets change to Slynd . but i am still spotting sometimes more sometimes less. my question is if i take a 1 week brake and resume taking pills will stop the spotting ?
we had sex about a week after i changed my pill to the desogestrel pill.
hi, i am taking ethinylestradiol/desogestrel richter 0.02 mg/0.15 mg, and i was supposed to start my 7 day pill free yesterday, but i forgot to, instead i started with my next strip of pill yesterday.. what should i suppose to do? should i stop taking the pill for the next 6 days and i will have my period in days or should i continue taking the pill for another 20 days?
Now since 2 weeks I also have mucus in my stool and I get very worried. I also take thyroid medication for Hashimoto and Desogestrel all the time for the Endometriosis. It would be great if anyone could help me. I went by the doctor already though they tell me to just eat healthy, which I do since 7 years now.
Would Mircette be an option with desogestrel being less angrogenic? Also, any experience with prescribed HALF tab of OC? (ie. instead of Loestrin 1/20.. use 0.5/10 for hormonal imbalance?) Just concerned about initial breakout.
Just some background... I have not used OC previously. I have no family history of breast cancer, no hypertension, non-smoker, and had 2 migraines in the past 5 years.
I can't help out on the pharmacokinetics, but your reasoning is sound: it doesn't make sense to dose so that the drug runs out.
I'd query Schering-Plough as well as your hepatologist, if I were you.
Please give me a heads-up if you solve the riddle.
II am trying to pin-point which of my female hormones is out of whack and causing, or at least contributing, to such terrible weekly Migraine headaches. Anyone know a good BC pill for individuals with severe, chronic Migraine headaches during ovulation AND menstruation?
I am 29 yrs old, average weight, in fair health, have never been pregnant, and started my period at age 11.
or combined oral contraceptive pill which contains two active ingredients, ethinylestradiol and desogestrel. It is used for regularizing the irregular periods.
In your case, since you had 3 abortions, so any adhesion formation causing difficulty in conceiving should also be explored and in this exploratory laparascopy is very helpful.
It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided.
Hepatic Impairment
In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (47% for Cmax and 85% for AUC). The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied. A starting dose of 25 mg should be considered in patients with any degree of hepatic impairment [see Dosage and Administration (2.5) and Clinical Pharmacology (12.3)].
Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..."
It however says that initiation of Folic acid and phenytoin together is beneficial.
Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
The Phase 1 trial was designed to characterize the safety profile of ARC-520 across a range of doses and evaluate pharmacokinetics. It is a single-center, randomized, double-blind, placebo-controlled, single dose-escalation, first-in-human study of ARC-520 administered intravenously to healthy adult volunteers. All subjects have been dosed and received either placebo or ARC-520 in doses ranging from 0.01 mg/kg to 2 mg/kg.
i believe in the pre-clinical trials with healthy volunteers, researchers used Carbon14 to gauge the half-life and paths of elimination during pharmacokinetics studies. it is a common practice. perhaps that is what you are thinking about?
Nitazoxanide, brand name alinia, had also excellent ed50 results in an in vitro inhibition study, just as good as lamuvidine, so this sounded fascinating for a possible combination towards true synergism, to finally suppress virion production to a level so low that the silent daily reinfection will be reduced, allowing a slow net clearance of infected cells with a resulting drop in surface antigen.
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