Cyclosporine modified dogs
Common Questions and Answers about Cyclosporine modified dogs
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and the vet will probably prescribe cyclosporine drops to help the eye produce more tears. Before you use the cyclosporine drops, be aware that they will sting your dogs eyes, and long term use may contribute to kidney disease...talk this over with your vet.
Since your dog is 12 years old, please have annual bloodwork done on him to assess liver and kidney functions...bloodwork should be done on all senior dogs.
Best Wishes for you and your dog.....
As a result, the skin around the eyes becomes red and inflamed looking, and it COULD have something to do with the redness and hair loss around the mouth as well, since these dogs have such short faces, the itchy eyes cause them to rub their faces on carpets, rough-textured furniture, etc., to seek relief from the itching. The excessive rubbing causes the redness and loss of hair. KCS is very common in all brachycephalic breeds (breeds with pushed-in faces) and breeds with bulging eyes.
Dry eye in dogs is treated with a drug called cyclosporine, which can only be obtained with a prescription from your vet. Please take her back to her former vet or find a new vet to prescribe this medicine for her. Her vision is in jeopardy without it.
About 6 months ago, I was finally diagnosed and started taking cyclosporine 100 mg 2x day. After a week, I could eat like a normal person—just about anything I wanted. It was great, it even allowed me to travel to Europe. The cyclosporine I was taking was a powder in a capsule, apparently this has been taken off the market and instead I took the same medication, but it was in the form of a capsule with alcohol. Unfortunately, after a short time, I was right back to before treatment.
Yes I took Cyclosporine for my aquagenic urticaria, it helped so much but not enough to have a normal life :S but maybe for you its going to be different...
I am still on 100 mg 2x daily cyclosporine. My cyclosporine through levels have been lower, the last time they were at 79. I Have been on 300 mg ursodiol 3x daily for biliary stricture since tx. I lowered the dose to 300mg once daily but just recently raised it back to 300x 3 daily because right side discomfort an increase in bilirubin. My headaches and fluid in ears have gotten better, still have the vision issues but heart palpitations have also lessened.
As a result he daily takes 75mg Deramaxx, 2 Glucosamine tablets, 50mg Tramadol, and 100mg Atopica (cyclosporine) with 200mg ketoconazole for an anal fistula problem. He had a yearly checkup 3 weeks ago. Bloodtest, wellness testing, vaccines, nails trimmed. They trimmed one nail too short, it bled alot, but they put a clotting agent on it. All blood levels were fine.
Pemphigus foliaceus is an autoimmune disease typically treated with steroids to get it under control and then a less strident topical or oral medication to keep the development of new blisters in check and prevent existing ones from becoming infected. Atopica is intended for in dogs with atopic dermatitis, so I don't know how this would be helpful to your cat and could be harmful since I don't think there have been any studies does regarding it's safety for cats.
The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus. She also said that because our dog doesn't have a dry, goopy nose, that pilocarpine wouldn't be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet.
Close to five years post liver transplant. No rejections, cyclosporine mono -therapy .Also take 300 mg ursodiol 3x daily for bile duct stricture. Vascular hyper-tensions are becoming a real concern. ie heart, palpitations . fluid in ears , vision problems that aren't related to my actual eyes, the opthamologist confirmed, Migraines that have actually gotten better lately. kidney function is still adequate. My liver is doing very good especially with hep-c..
Having worked for a vet dermatologist for years I can tell you that first off dogs cannot get poison ivy they are not affected by the oils but can transmit them to humans. Whenever I hear someone say hives or rash in a dog I chuckle because dogs don't get that either what you ARE seeing is bacterial infection of the skin which means you pup needs to see a vet asap and get some antibiotics to systemically clear things up. Finding the underlying cause is another issue to discuss.
In an additional 33 patients, glomerular and tubular NEP protein levels from renal graft biopsies were significantly higher among the 13 patients receiving cyclosporine + EC-MPS than among the 12 patients receiving cyclosporine + azathioprine or 8 patients receiving cyclosporine alone. Glomerular NEP expression inversely correlated with glomerulosclerosis and proteinuria, and tubular NEP expression inversely correlated with interstitial fibrosis.
I am currently under St Thomas hospital for this, they are stating I should take Cyclosporine for 6 months, I was wondering if someone on here has taken this treatment and it has worked for them??, I am not convinced on this medication as I have read so many bad things about it.
My consultant has stated that 70% of people whilst on cyclosporine will be clear, one third will have total remission,one third will be same as before, one third will be worse once the treatment has stopped.
We immediately put her on an antibiotic ointment and cyclosporine. It has been almost 10 days and while there is less discharge, she is still having some trouble opening her eye, she just keeps it closed (unless she gets excited). At some times you look at her and she looks completely fine, others times she can barely open her eye. Is this normal for KCS? Should we have seen some major improvement by now?
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