I take Diclofenac XR now and have had trouble with other prescription NSAIDs upsetting my stomach. For me, this one seems to be the best out of all I've tried and it's the most effective for my inflammation. I tried Mobic and Nabumatone and had problems with upset stomach and headache. In addition to Fibromyalgia I also have arthritis in my spine and shoulder, so I take it for that and I can't live without it. Ibuprofen and Naproxen doesn't even touch the inflammation and pain.