With Avonex and Rebif, it sometimes help to start out on less than the full
dose for several weeks, building up to the full dose later It really makes a difference, as some of our members will tell you. In fact, I truly believe that ALL new drugs, with the exception of antibiotics, should be started off slowly to give your body a chance to adapt. Too often, I have heard of doctor's starting patients off on full doses of medications, only to have to give them up, due to side-effects.