Candy, this really perplexes me, now.
Avonex is an interferon and it is known to have problems with
depression in some people, especially if they are already prone to depression. Our own dear Quix sunk quickly on Avonex and if I remember correctly, she didn't recognize how bad it was until she got off of it. Other people have absolutely no problems.
The Canadian system may not have approved payment for Gilenya, but that would surprise me.