Hi, antibiotics, such as amoxicillin for 2 weeks, have been the recommended first-line treatment of uncomplicated acute sinusitis. Amoxicillin-clavulanate (
Augmentin) is also an appropriate first-line
treatment of uncomplicated acute sinusitis. Other options include cephalosporins such as cefpodoxime proxetil (Vantin) and cefuroxime (Ceftin). In patients allergic to beta-lactams, trimethoprim-sulfamethoxazole (Bactrim), clarithromycin (Biaxin), and azithromycin.