Alendronate osteonecrosis
Common Questions and Answers about Alendronate osteonecrosis
boniva
The prescription drug Fosamax (the generic is alendronate sodium) is a medication which has been prescribed to hundreds of thousands of postmenopausal women to treat osteoporosis and help increase bone mass thereby reducing the chance of spinal or non-spinal fractures. Fosamax has also been prescribed to increase bone mass in men with osteoporosis. Brand name Fosamax is manufactured in the United States by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
There definitely is a connection between bisphosphonates like Fosamax and osteonecrosis of the jaws. This has been well established and documented in medical and dental journals.
An oral and maxillofacial surgeon is the type of doctor that most commonly diagnoses and treats this condition.
I took my first dose of Alendronate and then experience significant muscle pain for the next 4 days. Does anyone know if I should expect this to happen each time I take it or is it something to happen for the first few times until my body adjusts to the medicine?
Do you mean Fosamax (alendronate)? If you do, its for treating bone problems like Osteoperosis by adding bone mass and slows bone loss. I use it for Osteopenia.
It sounds like your surgeon is describing osteonecrosis. There is an entity known as "spontaneous onsteonecrosis of the knee." or "SPONK" This occurs rarely after knee after knee arthroscopy and can resolve after a period of rest and non-weight bearing. I t is not usually a reult of swelling. If anything, two weeks may be to soon to expect any change, either positive or negative, and often 6 weeks is used before re-evaluation.
The authors examined the effects of high-dose oral alendronate (40 mg daily) for 6 months on 3 adult patients with intractable headache due to fibrous dysplasia of the skull. Each patient had disease processes not amenable to surgery. The patients underwent clinical follow-up at 1, 3, and 6 months. Their pain levels were documented at each visit by using a visual analog scale. All 3 patients demonstrated a significant decrease in pain levels and became independent of scheduled analgesics.
If she has ever taken Boniva, she should worry. Google Osteonecrosis of the jaw, many drugs like Fosomax have bad side effects. A friend lost several teeth and parts of her jaw due to this. She eventually had to have cadaver bone to replace the bone she lost, then implants. She should take other types of calcium supplements.
There are reports that link people taking IV fosamx to osteonecrosis of the bone having oral and maxilofacial surgery. Treatment really depends upon degree of severity. Most of the time patients are advised hyperbaric chambers.
I am also taking Aromasin for bc. Stopped alendronate (I am osteopenic due to 30 yrs of prednisolone and Arimidex) in case this caused the oesophagitis. Would appreciate your advice.
thankyou,i am with contact of my doctor ,he said there is no solution for damaged vertibras,but calcium and vitiman d and alendronate sodium/cholecaiciferol tablets will help spine and bones from further damages but what to do with prednisones i cant stop them because of asthma and taking of them will damage other bones isnt there any other solution instead of prednisones, i know there is nothing accept these because my doctor told me:(
The authors examined the effects of high-dose oral alendronate (40 mg daily) for 6 months on 3 adult patients with intractable headache due to fibrous dysplasia of the skull. Each patient had disease processes not amenable to surgery. The patients underwent clinical follow-up at 1, 3, and 6 months. Their pain levels were documented at each visit by using a visual analog scale. All 3 patients demonstrated a significant decrease in pain levels and became independent of scheduled analgesics.
Osteoporosis medications like Raloxifene (Evista), alendronate (Fosomax), risendronate (Actonel) and ibandronate (Boniva) all can cause flu like symptoms in individuals that are taking them. I am not sure what medications you are on, but this could be your problem.
Ischemic osteonecrosis means, literally, "dead bone from poor blood flow."
The most important underlying, and almost always undiagnosed, susceptibility comes from coagulation disorders.
(Source: http://www.maxillofacialcenter.com/NICOcause.html )
Sometimes a person inherits the coagulation problem.
Hypercoagulation can also be associated with tick borne infection.
http://www.drcharlescrist.com/hypercoagulation.
No this is not from TMJ, I had osteonecrosis in my jawbone, had 3 surgeries and haven't had any pain since I was on the methadone but now that I am down to 18mgs the pain is starting to come through, my sister tells me it is rebound pain???
I think sometimes the radiologist can tell, like in my case, he highly suggested I had osteonecrosis of the femur rather than osteochronditis dissiccans, and which the radiologist thought after reading the bone scan because it was a hot lesion. It also said there was a large Baker's cyst.
Avasculary necrosis occurs when the blood supply to the bone is cut off for reasons of trauma or disease. This causes the bone in the area without blood supply to die and then to break down, often crumbling and failing to bear weight properly. Knee replacement can be done usually, depending on the location and size of the necrotic bone (I have a large lesion in a location that at present makes replacement impossible). It is also called osteonecrosis.
Nonunion or failure of the fracture to heal occurs in 10-30% of fractures of the neck of the femur (thigh bone) which is usually apparent within one year of the fracture and may be accompanied by osteonecrosis (bone death), irrespective of the cause of fracture. Majority of patients with non-union will require a re-operation.
yes, look at my questions about leg and knee pain and the results. Osteonecrosis. I also had the adriamycin/taxol/cytoxan/cortisone mixture, and radiation and now tamoxifen.
In our practice recommendations for Zometa or drugs in this class has to do with risk or or known osteopenia or osteonecrosis with the POSSIBLE added benefit of reducing risk of recurrence. These drugs are indicated to strengthen bones and any other benefit may be a bonus. You should have a discussion with your doctor about your own risks versus benefits.
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