I've tried Salex lotion, Aldara
, Amlactin, Keratol, Retin-A, and other prescription medications that did not work. Finally I went to a cosmetic dermatology laser clinic, and the doctor is removing them with an Erbium laser. They apply a numbing cream first for an hour, and then he lasers off the lesions. It is not painful, but a little bit uncomfortable. In the first treatment, he removed 100 lesions from my feet.